背景:分泌性癌(SC)是唾液腺的恶性肿瘤,在与神经营养性酪氨酸受体激酶融合阳性基因的关联方面与乳腺SC相似。SC是最近描述的唾液腺肿瘤,并且有一些报告描述了口腔小唾液腺衍生的SC。我们报告了2例SC在口腔中的病例,并进行了文献复习。
方法:患者包括一名65岁的日本女性上唇肿块和一名84岁的日本男性颊粘膜肿块。
方法:诊断基于组织形态学和免疫组织化学发现,并鉴定ETS变体6-神经营养受体酪氨酸激酶3基因融合体的特异性易位。使用福尔马林固定的石蜡包埋的组织样本,使用逆转录聚合酶链反应最终诊断病例1,而病例2使用荧光原位杂交分析诊断。
结果:在病例1中,进行了切除活检,在5年的随访中没有观察到复发。在病例2中,进行了肿瘤切除,并且在两年的随访中没有观察到复发。
结论:由于组织学发现相似,许多SC病例最初很可能被诊断为腺泡细胞癌(AciCC)。小唾液腺起源的SC的治疗策略与AciCC相似;但是,SC通常是高度恶性的,并且涉及颈淋巴结转移的高风险。因此,与病理学家一起建立准确的诊断,并使用遗传分析确认ETS变体6-神经营养受体酪氨酸激酶3融合基因的存在是重要的。
BACKGROUND: Secretory carcinoma (SC) is a malignancy of the salivary glands, which is similar to SC of the breast regarding its association with neurotrophic tyrosine receptor kinase fusion-positive gene. SC is a recently described salivary gland tumor, and there are a few
reports describing oral minor salivary gland-derived SC. We reported two cases of SC in the oral cavity and reviewed the literature.
METHODS: The patients included a 65-year-old Japanese woman who presented with a mass of the upper lip and an 84-year-old Japanese man who presented with a mass on the buccal mucosa.
METHODS: Diagnosis was based on histomorphological and immunohistochemical findings and identification of a specific translocation of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 gene fusion.
Case 1 was finally diagnosed using reverse transcription-polymerase chain reaction with formalin-fixed paraffin-embedded tissue samples, while
case 2 was diagnosed using fluorescence in situ hybridization analysis.
RESULTS: In
case 1, excisional biopsy was done and there was no recurrence observed in five-year follow-up. In
case 2, tumor resection was done and there was no recurrence observed in two-year follow-up.
CONCLUSIONS: It is highly likely for many cases of SC to be initially diagnosed as acinic cell carcinoma (AciCC) owing to their similar histological findings. The treatment strategy for minor salivary gland-originated SC is similar to that of AciCC; however, SC is often highly malignant and involves a high risk of cervical lymph node metastasis. Thus, establishing an accurate diagnosis together with pathologists and confirming the presence of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 fusion gene using genetic analysis is important.