PDF(Pubmed)
Abstract：
BACKGROUND: Secretory carcinoma (SC) has been described as a distinct salivary gland tumor in the fourth edition of the World Health Organization (WHO) classification of head and neck tumors. SC is generally considered as a slow-growing low-grade malignant tumor, while several cases have been reported with high-grade features, and even metastases in the literature up until now. In this article, a soft tissue SC case is discussed with high-grade microscopic features and neural invasion. A review of the salivary gland SC cases with aggressive behavior is also debated.
METHODS: A 65-year-old Caucasian man presented with a left neck mass for the past six months. The imaging studies demonstrated a very large cystic cervical mass (46 × 23 mm) with papillary projections in the anterolateral aspect of the left neck zone Vb. He underwent left radical neck dissection (level I-V) and was followed up for 12 months with the diagnosis of Secretory carcinoma.
CONCLUSIONS: Although SC generally has a good outcome, multiple recurrences and unusual metastases may occur, which should be considered by either the pathologists or clinicians.
METHODS: A 65-year-old Caucasian man presented with a left neck mass for the past six months. The imaging studies demonstrated a very large cystic cervical mass (46 × 23 mm) with papillary projections in the anterolateral aspect of the left neck zone Vb. He underwent left radical neck dissection (level I-V) and was followed up for 12 months with the diagnosis of Secretory carcinoma.
CONCLUSIONS: Although SC generally has a good outcome, multiple recurrences and unusual metastases may occur, which should be considered by either the pathologists or clinicians.
摘要：
背景：在世界卫生组织（WHO）头颈部肿瘤的第四版分类中，分泌性癌（SC）被描述为一种独特的唾液腺肿瘤。SC通常被认为是一种生长缓慢的低度恶性肿瘤，虽然已经报道了一些具有高级特征的病例，甚至直到现在文献中的转移。在这篇文章中,讨论了具有高级显微特征和神经浸润的软组织SC病例。还对具有攻击行为的唾液腺SC病例进行了审查。
方法：一名65岁的白种人在过去的6个月里出现了左颈肿块。影像学研究表明，颈部囊性肿块非常大（46×23mm），在左颈部Vb区的前外侧有乳头状突起。他接受了左根治性颈清扫术（I-V级），并随访了12个月，诊断为分泌性癌。
结论：尽管SC通常具有良好的结果，可能发生多次复发和异常转移，这应该由病理学家或临床医生考虑。
方法：一名65岁的白种人在过去的6个月里出现了左颈肿块。影像学研究表明，颈部囊性肿块非常大（46×23mm），在左颈部Vb区的前外侧有乳头状突起。他接受了左根治性颈清扫术（I-V级），并随访了12个月，诊断为分泌性癌。
结论：尽管SC通常具有良好的结果，可能发生多次复发和异常转移，这应该由病理学家或临床医生考虑。
