背景:最近,改变饮食习惯以控制心血管危险因素已得到广泛关注。然而,先前的研究在番茄红素和番茄消费对心血管危险因素的影响方面产生了不一致的结果.
目的:本研究的目的是评估食用番茄红素和西红柿对各种心血管危险因素的影响,如血脂,血糖控制标志物,血压,炎症,氧化应激,和体重。
方法:使用电子数据库进行了系统的文献检索,包括PubMed,WebofScience,还有Scopus,截至2022年11月,以确定合格的随机对照试验(RCT),评估番茄红素和番茄消费对心血管危险因素的影响。使用I2统计量对所选试验进行异质性检验。随机效应模型基于异质性测试进行评估,和合并数据确定为加权平均差(WMD),95%置信区间(CI).
结果:在最初确定的27,438条记录中,共有34项研究符合入选标准,并被纳入本荟萃分析.结果表明,番茄红素的消耗与丙二醛(MDA)水平的显着降低有关,表明在减少氧化应激方面具有潜在的益处。然而,食用番茄红素和番茄对其他心血管危险因素(如甘油三酯(TG))没有显着影响,总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),空腹血糖(FBG),收缩压(SBP),舒张压(DBP),细胞间粘附分子1(ICAM-1),C反应蛋白(CRP),白细胞介素6(IL-6),肿瘤坏死因子α(TNF-α),体重,体重指数(BMI)。
结论:总体而言,研究结果表明,番茄红素和番茄的消费不影响心血管危险因素。然而,补充番茄红素可导致MDA水平的显著改善。为了证实这些结果,需要进行长期持续和不同剂量的进一步研究.
In recent times, modifying dietary habits to control cardiovascular risk factors has gained significant attention. However, previous studies have yielded inconsistent results regarding the effects of
lycopene and tomato consumption on cardiovascular risk factors.
The objective of this study was to assess the impact of consuming
lycopene and tomatoes on various cardiovascular risks factors such as lipid profile, glycemic control markers, blood pressure, inflammation, oxidative stress, and body weight.
A systematic literature search was carried out using electronic databases, including PubMed, Web of Science, and Scopus, up to November 2022 to identify eligible Randomized Control Trials (RCTs) evaluating the effect of
lycopene and tomato consumption on cardiovascular risk factors. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference (WMD) with a 95% confidence interval (CI).
Out of 27,438 records initially identified, a total of 34 studies met the eligibility criteria and were included in this meta-analysis. The results showed that lycopene consumption was associated with a significant reduction in malondialdehyde (MDA) levels, indicating a potential benefit in reducing oxidative stress. However,
lycopene and tomato consumption did not have significant effects on other cardiovascular risk factors such as triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), Intercellular Adhesion Molecule 1 (ICAM-1), c-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), body weight, and body mass index (BMI).
Overall, the findings showed that lycopene and tomato consumption did not affect cardiovascular risk factors. However,
lycopene supplementation may result in a significant improvement in MDA levels. With the view to confirming these results, further studies with long-term duration and different doses are needed.