Abstract：
BACKGROUND: Oral submucous fibrosis (OSMF) is a well-known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients\' quality of life by enhancing mouth opening among others. Antioxidant treatment has shown promising results in inducing regression of lesions and preventing OSMF in high-risk individuals. This study investigates the effectiveness of various antioxidant agents against OSMF.
METHODS: The study followed PRISMA guidelines and searched three scientific databases: PubMed, Web of Science, and Scopus, using specific algorithms related to \"antioxidant treatment,\" \"burning sensation,\" and \"mouth opening.\" The quality assessment of controlled clinical studies adhered to Cochrane guidelines.
RESULTS: The analysis included 19 clinical trials comparing different treatments, including various antioxidants. Aloe vera, curcumin, and lycopene, among others, showed positive outcomes in treating OSMF by improving burning sensation, mouth opening, tongue protrusion, and cheek flexibility.
CONCLUSIONS: Antioxidant therapies are found to be effective in treating OSMF, even when compared to conventional treatments such as corticosteroids. The study highlights the need for further research and standardization of clinical protocols.
METHODS: The study followed PRISMA guidelines and searched three scientific databases: PubMed, Web of Science, and Scopus, using specific algorithms related to \"antioxidant treatment,\" \"burning sensation,\" and \"mouth opening.\" The quality assessment of controlled clinical studies adhered to Cochrane guidelines.
RESULTS: The analysis included 19 clinical trials comparing different treatments, including various antioxidants. Aloe vera, curcumin, and lycopene, among others, showed positive outcomes in treating OSMF by improving burning sensation, mouth opening, tongue protrusion, and cheek flexibility.
CONCLUSIONS: Antioxidant therapies are found to be effective in treating OSMF, even when compared to conventional treatments such as corticosteroids. The study highlights the need for further research and standardization of clinical protocols.
摘要：
背景：口腔粘膜下纤维化（OSMF）是一种众所周知的口腔癌前病变，以疤痕为特征，组织纤维化，和癌前病变。临床治疗的目标是通过增加张口来减少炎症并改善患者的生活质量。抗氧化剂治疗在诱导高风险个体的病变消退和预防OSMF方面显示出有希望的结果。这项研究调查了各种抗氧化剂对OSMF的有效性。
方法：这项研究遵循了PRISMA指南，并搜索了三个科学数据库：PubMed，WebofScience,还有Scopus,使用与“抗氧化剂治疗”相关的特定算法，\"\"烧灼感，“和”张嘴。“对照临床研究的质量评估符合Cochrane指南。
结果：分析包括19项比较不同治疗方法的临床试验，包括各种抗氧化剂。芦荟,姜黄素,还有番茄红素,其中,通过改善灼热感来治疗OSMF，张开嘴,舌头突出，和脸颊的灵活性。
结论：发现抗氧化疗法可有效治疗OSMF，即使与常规治疗如皮质类固醇相比。该研究强调了进一步研究和临床方案标准化的必要性。
方法：这项研究遵循了PRISMA指南，并搜索了三个科学数据库：PubMed，WebofScience,还有Scopus,使用与“抗氧化剂治疗”相关的特定算法，\"\"烧灼感，“和”张嘴。“对照临床研究的质量评估符合Cochrane指南。
结果：分析包括19项比较不同治疗方法的临床试验，包括各种抗氧化剂。芦荟,姜黄素,还有番茄红素,其中,通过改善灼热感来治疗OSMF，张开嘴,舌头突出，和脸颊的灵活性。
结论：发现抗氧化疗法可有效治疗OSMF，即使与常规治疗如皮质类固醇相比。该研究强调了进一步研究和临床方案标准化的必要性。
