PDF(Pubmed)
Abstract：
Aging and aging-related chronic disorders are one of the principal causes of death worldwide. The prevalence of these disorders is increasing gradually and globally. Considering this unwavering acceleration of the global burden, seeking alternatives to traditional medication to prevent the risk of aging disorders is needed. Among them, lycopene, a carotenoid, is abundant in many fruits and vegetables, including tomatoes, grapefruits, and watermelons, and it has a unique chemical structure to be a potent antioxidant compound. This nutraceutical also possesses several anti-aging actions, including combating aging biomarkers and ameliorating several chronic disorders. However, no systematic evaluation has yet been carried out that can comprehensively elucidate the effectiveness of lycopene in halting the course of aging and the emergence of chronic diseases linked to aging. This review, therefore, incorporates previous pre-clinical, clinical, and epidemiological studies on lycopene to understand its potency in treating aging disorders and its role as a mimic of caloric restriction. Lycopene-rich foods are found to prevent or attenuate aging disorders in various research. Based on the evidence, this review suggests the clinical application of lycopene to improve human health and alleviate the prevalence of aging and aging disorders.
摘要：
衰老和与衰老相关的慢性疾病是全世界死亡的主要原因之一。这些疾病的患病率在全球范围内逐渐增加。考虑到全球负担的不断加剧，需要寻找传统药物的替代品，以防止衰老疾病的风险。其中,番茄红素,类胡萝卜素，富含许多水果和蔬菜，包括西红柿,葡萄柚,还有西瓜,它具有独特的化学结构，是一种有效的抗氧化化合物。这种营养食品还具有几种抗衰老作用，包括对抗衰老生物标志物和改善几种慢性疾病。然而,尚未进行系统的评估，可以全面阐明番茄红素在阻止衰老过程和与衰老相关的慢性疾病出现方面的有效性。这次审查,因此,结合了以前的临床前，临床,以及对番茄红素的流行病学研究，以了解其治疗衰老障碍的功效及其作为热量限制的模拟作用。在各种研究中发现富含番茄红素的食物可以预防或减轻衰老障碍。根据证据,本文综述了番茄红素在改善人类健康、缓解衰老和衰老障碍方面的临床应用。
