背景:怀孕的成功取决于各种因素,子宫内膜容受性是至关重要的组成部分。子宫内膜厚度(EMT)是评估子宫内膜容受性的直接指标。以前的研究表明,子宫内膜薄与较低的妊娠率有关,尤其是EMT小于4毫米的患者。即使在辅助生殖技术周期中成功率很高,据报道,子宫内膜薄的患者的临床妊娠病例很少,更不用说自然概念循环了。因此,薄薄的子宫内膜对不孕症患者构成重大挑战。在这项研究中,子宫内膜极薄的患者能够通过自然受孕实现临床妊娠和成功活产,强调成功的可能性,即使在具有挑战性的情况下。
方法:患者表现为多囊卵巢综合征和排卵障碍。她经历了来曲唑诱导排卵的自然周期。在人类绒毛膜促性腺激素触发的那天,她的EMT为3.8毫米.
方法:多囊卵巢综合征,排卵障碍,薄薄的子宫内膜。
方法:患者接受了包括Progynova在内的药物治疗,阿司匹林,和地屈孕酮.
结果:患者实现了自发受孕,随后进行了活产。
结论:该病例报告强调了在来曲唑诱导排卵期间管理薄型子宫内膜的重要性。虽然EMT传统上是预测胚胎植入成功的关键,我们的研究结果表明,子宫内膜容受性超出了单独的厚度.子宫内膜形态学等因素,type,血液供应起着至关重要的作用。3.8毫米EMT成功怀孕很少见,使这个案子成为这些病人的希望灯塔。它强调,通过适当的干预,成功的怀孕仍然可以实现。对于那些子宫内膜薄的人来说,重点应该超越厚度,解决方法,以提高子宫内膜的血液供应和形态,提高妊娠率。
BACKGROUND: The success of pregnancy depends on various factors, with the endometrial receptivity being a crucial component. Endometrial thickness (EMT) serves as a direct indicator for assessing endometrial receptivity. Previous studies have suggested that a thin endometrium is associated with lower pregnancy rates, especially in patients with an EMT of less than 4 mm. Even in assisted reproductive technology cycles with high success rates, clinical pregnancy cases in patients with such thin endometrium are reported to be very few, let alone in natural conception cycles. Therefore, a thin endometrium poses significant challenges for infertility patients. In this study, patients with an extremely thin endometrium were able to achieve clinical pregnancy and successful live births through natural conception, highlighting the possibility of success even in challenging cases.
METHODS: The patient presented with polycystic ovary syndrome and ovulation disorders. She underwent a natural cycle of letrozole-induced ovulation. On the day of the human chorionic gonadotropin trigger, she had an EMT of 3.8 mm.
METHODS: Polycystic ovary syndrome, ovulation disorders, thin endometrium.
METHODS: The patient received medications including Progynova, Aspirin, and Dydrogesterone.
RESULTS: The patient achieved spontaneous conception and subsequently had a live birth.
CONCLUSIONS: This
case report underscores the significance of managing a thin endometrium during letrozole-induced ovulation. While EMT is traditionally pivotal for predicting embryo implantation success, our findings indicate that endometrial receptivity extends beyond thickness alone. Factors such as endometrial morphology, type, and blood supply play crucial roles. Successful pregnancies with a 3.8 mm EMT are rare, making this
case a beacon of hope for such patients. It highlights that, with appropriate interventions, successful pregnancies remain attainable. For those with a thin endometrium, emphasis should extend beyond thickness, addressing ways to enhance both endometrial blood supply and morphology for improved pregnancy rates.