%0 Journal Article
%T In vitro fertilization and pregnancy outcomes of women with X chromosome abnormality: A case series.
%A Wang R
%A Zhang L
%A Liao J
%A Ma F
%A Ma Q
%J Birth Defects Res
%V 116
%N 5
%D 2024 May
%M 38778782
暂无%R 10.1002/bdr2.2349
%X <B>BACKGROUND: </B>To describe and conclude the in vitro fertilization (IVF) results of patients with X chromosome abnormality.<BR><B>METHODS: </B>A retrospective case series was conducted. According to the number of normal X, patients were allocated into two groups: Group A (patients with only a normal X, while other X has any types of abnormalities) and Group B (patients have two or more normal X chromosomes). Clinical data, including basic information, fertility information, and IVF outcomes, were collected.<BR><B>RESULTS: </B>Fourteen patients with X chromosome abnormality were included, among which 13 patients underwent a total of 29 cycles. Patients in Group B had five successful pregnancies and three live births, while no patient in Group A had a clinical pregnancy. Furthermore, the blastocyst formation rate and incidence of pregnancy were significantly lower in Group A (Z = -3.135, p = .002; Z = -2.946, p = .003, respectively). When controlled covariates, the karyotype of one normal X was also a risk factor for both blastocyst formation rate and success pregnancy (β = .820, 95% confidence interval [CI] = 0.458-1.116, β = .333, 95% CI = 0.017-0.494, respectively).<BR><B>CONCLUSIONS: </B>Our results revealed that women with only one normal X might suffer from worse IVF outcomes, mainly blastocyst formation rate, compared with those who had two or more normal X, including mosaic Turner syndrome and 47,XXX.