Abstract：
Oocytes with excessively large first polar bodies (PB1) often occur in assisted reproductive procedures. Many times these oocytes are discarded without insemination and, as a result, the application of this portion of oocytes has scarcely been reported to date. Few studies have examined large PB1 oocytes in infertile women and have virtually entirely studied genetic variations for large PB1 oocyte abnormalities. Here, we describe an unusual case of a live birth from a remarkably large PB1 oocyte in a frozen embryo transfer (FET) cycle. This is the first instance of a successful live birth resulting from a PB1 oocyte with an extremely large polar body measuring 80 μM × 40 μM in size. The large PB1 oocyte was performed by an early rescue intracytoplasmic sperm injection (r-ICSI) and was formed into a blastocyst on day 5. Following FET, a healthy boy baby weighing 3100 g was finally delivered by caesarean section at 37 weeks and 5 days after conception. Additionally, there were no complications throughout the antenatal period or the perinatal phase of this following full-term delivery. In this study, it is revealed for the first time that a huge PB1 oocyte can be fertilized, resulting in the growth of a blastocyst, a subsequent pregnancy, and a live birth. This new information prompts us to reconsider the use of large PB1 oocytes. More insightful talks should be given attention to prevent the waste of embryos because not all oocytes with aberrant morphology are unavailable.
摘要：
第一极体（PB1）过大的卵母细胞通常发生在辅助生殖程序中。很多时候，这些卵母细胞在没有授精的情况下被丢弃，因此,该部分卵母细胞的应用至今几乎没有报道。很少有研究检查不育妇女的大型PB1卵母细胞，并且几乎完全研究了大型PB1卵母细胞异常的遗传变异。这里,我们描述了在冷冻胚胎移植（FET）周期中，一个非常大的PB1卵母细胞活产的不寻常情况。这是由PB1卵母细胞产生的成功活产的第一个实例，该卵母细胞的极体大小为80μM×40μM。大的PB1卵母细胞通过早期拯救胞浆内单精子注射（r-ICSI）进行，并在第5天形成胚泡。在FET之后,在受孕后37周和5天，一个体重3100克的健康男婴最终通过剖腹产分娩。此外,足月分娩后的整个产前或围产期均未出现并发症.在这项研究中,首次揭示了巨大的PB1卵母细胞可以受精，导致胚泡的生长，随后的怀孕，和活产。这些新信息促使我们重新考虑使用大型PB1卵母细胞。应该注意更多有见地的讨论，以防止胚胎的浪费，因为并非所有形态异常的卵母细胞都不可用。
