PDF(Pubmed)
Abstract：
OBJECTIVE: Failure to collect oocytes at the time of oocyte pick-up is an unfavorable outcome of in vitro fertilization (IVF) cycles. In these cases, prompt intrauterine insemination (IUI) could be an option (rescue IUI), but this possibility has been poorly studied.
METHODS: Rescue IUI is routinely offered in our unit in women failing to retrieve oocytes, provided that they have at least one patent tube, normal male semen analysis, and the total number of developed follicles is ≤ 3. We therefore reviewed all oocyte retrievals performed from 2006 to 2022 in our unit to identify these cases. As a comparator, we referred to preplanned IUI performed during the same study period. The 95% confidence interval (95% CI) of proportions was calculated using a binomial distribution model.
RESULTS: Rescue IUI was performed in 96 out of 3531 oocyte retrievals (2.7%; 95% CI 2.2-3.3%). Six live births were obtained, corresponding to 6.2% (95% CI 2.3-13.1). All pregnancies were singletons.
CONCLUSIONS: Rescue IUI in women failing to retrieve oocytes is a possible option that may be considered in selected cases. The efficacy is low, but the procedure is simple, and without significant risks. Generalizability to a conventional IVF protocol setting is however limited.
METHODS: Rescue IUI is routinely offered in our unit in women failing to retrieve oocytes, provided that they have at least one patent tube, normal male semen analysis, and the total number of developed follicles is ≤ 3. We therefore reviewed all oocyte retrievals performed from 2006 to 2022 in our unit to identify these cases. As a comparator, we referred to preplanned IUI performed during the same study period. The 95% confidence interval (95% CI) of proportions was calculated using a binomial distribution model.
RESULTS: Rescue IUI was performed in 96 out of 3531 oocyte retrievals (2.7%; 95% CI 2.2-3.3%). Six live births were obtained, corresponding to 6.2% (95% CI 2.3-13.1). All pregnancies were singletons.
CONCLUSIONS: Rescue IUI in women failing to retrieve oocytes is a possible option that may be considered in selected cases. The efficacy is low, but the procedure is simple, and without significant risks. Generalizability to a conventional IVF protocol setting is however limited.
摘要：
目的：取卵时未能收集卵母细胞是体外受精（IVF）周期的不利结果。在这些情况下,及时宫腔内人工授精(IUI)可能是一种选择(救援IUI)，但是这种可能性研究得很少。
方法：RescueIUI通常在我们的单位中提供，用于未能取回卵母细胞的女性，只要他们至少有一根专利管，正常男性精液分析,发育的卵泡总数≤3。因此，我们回顾了2006年至2022年在我们单位进行的所有卵母细胞检索，以识别这些病例。作为一个比较器，我们参考了在同一研究期间进行的预先计划的IUI.使用二项分布模型计算比例的95%置信区间(95%CI)。
结果：在3531个卵母细胞中的96个中进行了拯救IUI（2.7％；95％CI2.2-3.3％）。获得了六个活产，对应于6.2%（95%CI2.3-13.1）。所有怀孕都是单身。
结论：对于未能获取卵母细胞的女性，挽救IUI是一个可能的选择，在某些情况下可以考虑。疗效低，但是程序很简单，没有重大风险。然而,对常规IVF协议设置的通用化是有限的。
方法：RescueIUI通常在我们的单位中提供，用于未能取回卵母细胞的女性，只要他们至少有一根专利管，正常男性精液分析,发育的卵泡总数≤3。因此，我们回顾了2006年至2022年在我们单位进行的所有卵母细胞检索，以识别这些病例。作为一个比较器，我们参考了在同一研究期间进行的预先计划的IUI.使用二项分布模型计算比例的95%置信区间(95%CI)。
结果：在3531个卵母细胞中的96个中进行了拯救IUI（2.7％；95％CI2.2-3.3％）。获得了六个活产，对应于6.2%（95%CI2.3-13.1）。所有怀孕都是单身。
结论：对于未能获取卵母细胞的女性，挽救IUI是一个可能的选择，在某些情况下可以考虑。疗效低，但是程序很简单，没有重大风险。然而,对常规IVF协议设置的通用化是有限的。
