肠道胆固醇吸收在个体之间差异很大,这可能会转化为对降胆固醇药物或饮食的反应差异。因此,了解遗传变异对胆固醇吸收率和复杂的肠道胆固醇网络的重要性。在系统回顾的基础上,七个基因的遗传变异(ABCG5,ABCG8,ABO,APOE,MTTP,NPC1L1和LDLR)与肠道胆固醇吸收有关。APOA4、APOB、CETP,CYP7A1,HMGCR,SCARB1、SLCO1B1和SREBF1。这7个基因用于构建肠道胆固醇吸收网络。最后,一个有15个额外基因的网络(APOA1,APOA4,APOB,APOC2,APOC3,CETP,HSPG2,LCAT,LDLRAP1、LIPC、LRP1,OLR1,P4HB,SAR1B,和SDC1)产生。所构建的网络显示胆固醇吸收是复杂的。需要进一步的研究来验证和改进这个网络,这可能最终导致更好地理解肠道胆固醇吸收的广泛个体间差异和个性化干预措施的发展。
Intestinal cholesterol absorption varies widely between individuals, which may translate into differences in responsiveness to cholesterol-lowering drugs or diets. Therefore, understanding the importance of genetic variation on cholesterol absorption rates and the complex intestinal cholesterol network is important. Based on a systematic
review, genetic variants in seven genes (ABCG5, ABCG8, ABO, APOE, MTTP, NPC1L1, and LDLR) were identified that were associated with intestinal cholesterol absorption. No clear associations were found for variants in APOA4, APOB, CETP, CYP7A1, HMGCR, SCARB1, SLCO1B1, and SREBF1. The seven genes were used to construct an intestinal cholesterol absorption network. Finally, a network with fifteen additional genes (APOA1, APOA4, APOB, APOC2, APOC3, CETP, HSPG2, LCAT, LDLRAP1, LIPC, LRP1, OLR1, P4HB, SAR1B, and SDC1) was generated. The constructed network shows that cholesterol absorption is complex. Further studies are needed to validate and improve this network, which may ultimately lead to a better understanding of the wide inter-individual variability in intestinal cholesterol absorption and the development of personalized interventions.