%0 Journal Article
%T Fat malabsorption in short bowel syndrome: A review of pathophysiology and management.
%A Hirsch TI
%A Wang SZ
%A Fligor SC
%A Quigley M
%A Gura KM
%A Puder M
%A Tsikis ST
%J Nutr Clin Pract
%V 39
%N 0
%D 2024 Apr
%M 38429962
%F 3.204
%R 10.1002/ncp.11119
%X Fat malabsorption is central to the pathophysiology of short bowel syndrome (SBS). It occurs in patients with insufficient intestinal surface area and/or function to maintain metabolic and growth demands. Rapid intestinal transit and impaired bile acid recycling further contribute to fat malabsorption. A significant portion of patients require parenteral nutrition (PN) for their survival but may develop sepsis and liver dysfunction as a result. Despite advancements in the treatment of SBS, fat malabsorption remains a chronic issue for this vulnerable patient population. Peer-reviewed literature was assessed on the topic of fat malabsorption in SBS. Current management of patients with SBS involves dietary considerations, PN management, antidiarrheals, glucagon-like peptide 2 agonists, and multidisciplinary teams. Clinical trials have focused on improving intestinal fat absorption by facilitating fat digestion with pancreatic enzymes. Targeting fat malabsorption in SBS is a potential pathway to improving lifestyle and reducing morbidity and mortality in this rare disease.