神经病影响普通人群的7-10%,是由体感系统的病变或疾病引起的。目前的治疗方法的局限性突出了一种新的创新方法来治疗神经性疼痛(NP)的必要性,基于氧化应激之间的密切相关,炎症过程,和抗氧化作用。由啤酒花提取物组成的新型组合的有利结果,蜂胶,银杏,维生素B,在这项研究中评估了用作治疗的棕榈酰乙醇胺(PEA)。为了评估组合的吸收和生物分布,其生物利用度首先在复制肠道吸收的3D肠道屏障模型中进行检查.Further,开发了3D神经组织模型来研究在NP涉及的基本途径期间组合的生物学影响。我们的发现表明,这种组合可以穿过肠屏障并到达周围神经系统,它调节氧化应激,炎症水平,和髓鞘形成机制(增加NRG,MPZ,ERB,和p75水平)在雪旺氏细胞损伤下。这项研究证明了银杏的有效性,蜂胶,啤酒花提取物,维生素B,和PEA可以避免神经损伤,并建议了NP和神经病的潜在替代营养治疗。
Neuropathy affects 7-10% of the general population and is caused by a lesion or disease of the somatosensory system. The limitations of current therapies highlight the necessity of a new innovative approach to treating neuropathic pain (NP) based on the close correlation between oxidative stress, inflammatory process, and antioxidant action. The advantageous outcomes of a novel combination composed of Hop extract, Propolis, Ginkgo Biloba, Vitamin B, and palmitoylethanolamide (PEA) used as a treatment was evaluated in this
study. To assess the absorption and biodistribution of the combination, its bioavailability was first examined in a 3D intestinal barrier model that replicated intestinal absorption. Further, a 3D nerve tissue model was developed to
study the biological impacts of the combination during the essential pathways involved in NP. Our findings show that the combination could cross the intestinal barrier and reach the peripheral nervous system, where it modulates the oxidative stress, inflammation levels, and myelination mechanism (increased NRG, MPZ, ERB, and p75 levels) under Schwann cells damaging. This
study proves the effectiveness of Ginkgo Biloba, Propolis, Hop extract, Vitamin B, and PEA in avoiding nerve damage and suggests a potential alternative nutraceutical treatment for NP and neuropathies.