{Reference Type}: Journal Article
{Title}: Fat malabsorption in short bowel syndrome: A review of pathophysiology and management.
{Author}: Hirsch TI;Wang SZ;Fligor SC;Quigley M;Gura KM;Puder M;Tsikis ST;
{Journal}: Nutr Clin Pract
{Volume}: 39
{Issue}: 0
{Year}: 2024 Apr
{Factor}: 3.204
{DOI}: 10.1002/ncp.11119
{Abstract}: Fat malabsorption is central to the pathophysiology of short bowel syndrome (SBS). It occurs in patients with insufficient intestinal surface area and/or function to maintain metabolic and growth demands. Rapid intestinal transit and impaired bile acid recycling further contribute to fat malabsorption. A significant portion of patients require parenteral nutrition (PN) for their survival but may develop sepsis and liver dysfunction as a result. Despite advancements in the treatment of SBS, fat malabsorption remains a chronic issue for this vulnerable patient population. Peer-reviewed literature was assessed on the topic of fat malabsorption in SBS. Current management of patients with SBS involves dietary considerations, PN management, antidiarrheals, glucagon-like peptide 2 agonists, and multidisciplinary teams. Clinical trials have focused on improving intestinal fat absorption by facilitating fat digestion with pancreatic enzymes. Targeting fat malabsorption in SBS is a potential pathway to improving lifestyle and reducing morbidity and mortality in this rare disease.