UNASSIGNED:弓形虫感染(弓形虫病)有可能在免疫功能低下的患者中引起严重疾病,并且在该人群中可能致命。我们进行了系统评价和荟萃分析,以全面评估包括HIV/AIDS患者在内的免疫功能低下患者中弓形虫病的合并血清阳性率。癌症患者,和伊朗的移植接受者。
未经授权:PubMed,WebofScience,Scopus,Embase,和谷歌学者数据库(国际)和科学信息数据库(SID),马吉兰,IranMedex,对所有可能包含2013年至2022年伊朗不同免疫功能低下人群弓形虫患病率数据的报告进行了系统搜索。
未经评估:总的来说,伊朗免疫功能低下患者弓形虫病的IgG血清阳性率为45.1%(95%置信区间(CI),37.4-52.9).在包括2279名癌症患者的12项研究中,弓形虫病的IgG血清阳性率,包括2565名HIV/AIDS患者的19项研究和包括200名移植受者的3项研究为43.6%(95%CI,30.2-57.0),45.9%(95%CI,34.8-57.1)和45.8%(95%CI,32.5-59.0),分别。此外,26项研究的IgM血清阳性率为2.6%(95%CI,1.4-3.7)。
未经证实:我们的发现代表免疫功能低下患者中弓形虫IgG的高血清阳性率。对于这些易感人群,健康改善和预防弓形虫病的教育非常重要。
UNASSIGNED: Toxoplasma gondii infection (toxoplasmosis) has the potential to cause a serious disease in immunocompromised patients and can be fatal in this population. We conducted a systematic
review and meta-analysis to assess comprehensively the pooled seroprevalence of toxoplasmosis among immunocompromised patients including HIV/AIDS patients, cancer patients, and transplant recipients in Iran.
UNASSIGNED: PubMed, Web of Science, Scopus, Embase, and Google Scholar databases (international) and Scientific Information Database (SID), Magiran, IranMedex, and IranDoc databases (national) were systematically searched for all reports that possibly contained data for T. gondii prevalence in different immunocompromised populations in Iran between 2013 and 2022.
UNASSIGNED: Overall, IgG seroprevalence rate of toxoplasmosis in Iranian immunocompromised patients was 45.1% (95% confidence interval (CI), 37.4-52.9). IgG seroprevalence rate of toxoplasmosis in 12 studies that included 2279 cancer patients, 19 studies that included 2565 HIV/AIDS patients and in 3 studies that included 200 transplant recipients was 43.6% (95% CI, 30.2-57.0), 45.9% (95% CI, 34.8-57.1) and 45.8% (95% CI, 32.5-59.0), respectively. Moreover, IgM seroprevalence rate in the 26 studies was 2.6% (95% CI, 1.4-3.7).
UNASSIGNED: Our findings represent a high seroprevalence rate of Toxoplasma IgG among immunocompromised patients. Health improvement and education toward prevention of toxoplasmosis is of great importance for these susceptible populations.