PDF(Pubmed)
Abstract：
Bowen\'s disease represents the in situ form of cutaneous squamous cell carcinoma; although it has an excellent prognosis, 3-5% of lesions progress to invasive cutaneous squamous cell carcinoma, with a higher risk in immunocompromised patients. Treatment is therefore always necessary, and conventional photodynamic therapy is a first-line option. The aim of this review is to provide an overview of the clinical response, recurrence rates, safety, and cosmetic outcome of photodynamic therapy in the treatment of Bowen\'s disease, considering different protocols in terms of photosensitizers, light source, and combination treatments. Photodynamic therapy is a valuable option for tumors at sites where wound healing is poor/delayed, in the case of multiple and/or large tumors, and where surgery would be difficult or invasive. Dermoscopy and reflectance confocal microscopy can be used as valuable tools for monitoring the therapeutic response. The treatment is generally well tolerated, with mild side effects, and is associated with a good/excellent cosmetic outcome. Periodic follow-up after photodynamic therapy is essential because of the risk of recurrence and progression to cSCC. As the incidence of keratinocyte tumors increases, the therapeutic space for photodynamic therapy will further increase.
摘要：
Bowen病代表皮肤鳞状细胞癌的原位形式;虽然它有良好的预后,3-5%的病变进展为侵袭性皮肤鳞状细胞癌，免疫功能低下患者的风险较高。因此，治疗总是必要的，而传统的光动力疗法是一线选择。这篇综述的目的是提供临床反应的概述，复发率,安全,和美容结果的光动力疗法在治疗鲍恩病，考虑到光敏剂方面的不同方案，光源,和组合治疗。对于伤口愈合不良/延迟的部位的肿瘤，光动力疗法是一种有价值的选择。在多发性和/或大型肿瘤的情况下，以及手术困难或侵入性的地方。皮肤镜检查和反射共聚焦显微镜可以用作监测治疗反应的有价值的工具。治疗通常耐受性良好，有轻微的副作用，并与良好/出色的美容效果相关。由于复发和进展为cSCC的风险，光动力疗法后的定期随访是必不可少的。随着角质形成细胞肿瘤发病率的增加，光动力疗法的治疗空间将进一步增加。
