■在精神分裂症中,精神运动速度受损是预测更差的功能结局的常见症状。炎症引起白质完整性的变化,这可能会导致精神运动速度降低。因此,我们希望调查使用细胞因子评估的外周炎症是否影响一系列精神病患者的精神运动速度表现.
■本研究是一项前瞻性队列研究,包括来自务实的参与者,随机对照试验比较了三种非典型抗精神病药物在一系列精神病患者中的应用。出于本子研究的目的,我们对药物治疗组进行了总体分析.在基线时评估精神运动速度,在随访的第6、12、26和52周,使用神经心理学测试跟踪测试(TMT)A和B,和符号编码。测量以下细胞因子的血清浓度:白细胞介素(IL)-β,IL-2、IL-4、IL-6、IL-10、IL-12p70、IL-17a、干扰素(IFN)-γ和肿瘤坏死因子(TNF)-α。在基线和1、3、6、12、26、39和52周后收集血液样品。我们在线性混合效应模型中分析了细胞因子水平随时间变化对精神运动速度的影响。
■在我们控制可能的混杂因素的线性混合效应模型中,IFN-γ对TMT-A和符号编码性能具有显著的负面影响。精神运动速度的其他测试均未与细胞因子显着相关。在整个研究期间,总体精神运动速度表现显着增加,而细胞因子水平保持稳定。
■我们的研究表明IFN-γ与精神运动速度之间呈负相关,当了解精神病患者精神运动偏差背后的机制时,这可能很重要。
UNASSIGNED: In schizophrenia, impaired psychomotor speed is a common symptom predicting worse functional outcome. Inflammation causes changes in white matter integrity, which may lead to reduced psychomotor speed. Therefore, we wanted to investigate if peripheral inflammation assessed with cytokines affected performance on psychomotor speed in patients with a spectrum of psychotic disorders.
UNASSIGNED: The current
study is a prospective cohort
study, including participants from a pragmatic, randomised controlled
trial comparing three atypical antipsychotics in patients with a spectrum of psychotic disorders. For the purposes of this sub-
study, we analysed drug treatment groups collectively. Psychomotor speed was assessed at baseline, and at weeks 6, 12, 26 and 52 of follow-up, using the neuropsychological tests trail making test (TMT) A and B, and symbol coding. Serum concentration of the following cytokines were measured: interleukin (IL)-β, IL-2, IL-4, IL-6, IL-10, IL12 p70, IL-17a, interferon (IFN)-γ and tumor necrosis factor (TNF)-α. Blood samples were collected at baseline and after 1, 3, 6, 12, 26, 39 and 52 weeks. We analysed the effect of cytokines levels on psychomotor speed over time in linear mixed effects models.
UNASSIGNED: In our linear mixed effects models controlling for possible confounders, IFN-γ had a significant negative effect on TMT-A and symbol coding performance. None of the other tests for psychomotor speed were significantly associated with cytokines. Overall psychomotor speed performance increased significantly across the
study period while cytokine levels remained stable.
UNASSIGNED: Our
study indicates a negative association between IFN-γ and psychomotor speed, which might be of importance when understanding the mechanisms behind psychomotor deviations in psychotic disorders.