背景:对特应性皮炎(AD)患者感染COVID-19的风险了解不完全。
目的:评估AD患者COVID-19感染的风险,多样化的队列。
方法:一项病例对照研究,旨在分析AD与COVID-19的相关性。使用多变量分析比较病例和对照之间的合并症和危险因素。
结果:在一组11,752例AD病例和47,008例匹配对照中,AD患者更有可能诊断为COVID-19(4.2%vs2.8%,P<.001)。在多变量分析中,AD与COVID-19仍然显著相关(比值比,1.29;P<.001)调整人口因素和合并症后。
结论:使用电子健康记录确定AD和COVID-19病例,缺乏关于AD严重程度或治疗和COVID-19结局的临床数据。
结论:AD与COVID-19感染的几率增加相关,即使在控制了常见的合并症之后。
BACKGROUND: There is an incomplete understanding of the risk of COVID-19 infection in atopic dermatitis (AD) patients.
OBJECTIVE: To evaluate the risk of COVID-19 infection in AD patients in a large, diverse cohort.
METHODS: A
case-control study of the All of Us cohort to analyze the association between AD and COVID-19. Comorbidities and risk factors were compared between cases and controls using multivariable analyses.
RESULTS: In a cohort of 11,752 AD cases with 47,008 matched controls, AD patients were more likely to have a COVID-19 diagnosis (4.2% vs 2.8%, P < .001). AD remained significantly associated with COVID-19 in multivariable analysis (odds ratio, 1.29; P < .001) after adjusting for demographic factors and comorbidities.
CONCLUSIONS: Ascertainment of AD and COVID-19 cases using electronic health records and lack of clinical data on AD severity or therapy and COVID-19 outcomes.
CONCLUSIONS: AD is associated with increased odds of COVID-19 infection even after controlling for common comorbidities.