Effect of Crizanlizumab, a P-Selectin Inhibitor, in COVID-19: A Placebo-Controlled, Randomized Trial.

• 影响指数: 9.531
• 发表时间: Dec 2021
• 来源期刊: JACC Basic Transl Sci
• DOI: 10.1016/j.jacbts.2021.09.013
• PMID: 34904132
• 文章类型: Journal Article
• 作者列表: Leucker TM,Osburn WO,Reventun P,Smith K,Claggett B,Kirwan BA,de Brouwer S,Williams MS,Gerstenblith G,Hager DN,Streiff MB,Solomon SD,Lowenstein CJ

关键词: CRP, C-reactive protein; IL, interleukin; TAT, thrombin antithrombin; TNF, tumor necrosis factor; VTE, venous thromboembolism; VWF, von Willebrand factor; coronavirus; crizanlizumab; endothelial; exocytosis; inflammation; thrombosis

Abstract

COVID-19 is characterized by vascular inflammation and thrombosis, including elevations in P-selectin, a mediator of inflammation released by endothelial cells. We tested the effect of P-selectin inhibition on biomarkers of thrombosis and inflammation in patients with COVID-19. Hospitalized patients with moderate COVID-19 were randomly assigned to receive either placebo or crizanlizumab, a P-selectin inhibitor, in a double-blind fashion. Crizanlizumab reduced P-selectin levels by 89%. Crizanlizumab increased D-dimer levels by 77% and decreased prothrombin fragment. There were no significant differences between crizanlizumab and placebo for clinical endpoints. Crizanlizumab was well tolerated. Crizanlizumab may induce thrombolysis in the setting of COVID-19. (Crizanlizumab for Treating COVID-19 Vasculopathy [CRITICAL]; NCT04435184).