背景:一些研究强调了晚期糖基化终产物可溶性受体(sRAGE)对肥胖可能的积极作用。然而,由于结果不一致,本系统综述和荟萃分析旨在定量评估和批判性地审查评估成年人群sRAGE与肥胖之间关系的研究结果.
方法:在系统搜索中,资格标准如下:采用横断面设计进行的研究,包括显然健康的成年人,成人肥胖,或者肥胖相关疾病,18岁以上,并评估了一般或中心性肥胖指数与sRAGE之间的关系。
结果:我们在电子数据库中的系统搜索,包括PubMed,Scopus,和Embase直到10月26日,2023年共发表了21,612篇文章。删除重复项后,筛选标题和摘要,阅读全文,最终的荟萃分析包括13份手稿。根据我们的结果,那些在最高类别的循环sRAGE浓度中值934.92pg/ml的sRAGE,具有1.9kg/m2较低的体重指数(BMI)(WMD:-1.927;CI:-2.868,-0.986;P<0.001),而sRAGE浓度最低类别的中位数为481.88pg/ml。此外,处于最高sRAGE类别,中值为1302.3pg/mlsRAGE,与最低sRAGE浓度类别的患者相比,伴有近6厘米的低腰围(WC)(WMD:-5.602;CI:-8.820,-2.383;P<0.001,I2的异质性为86.4%),中位数为500.525pg/ml。肥胖个体的循环sRAGE浓度显著较低(WMD:-135.105;CI:-256.491,-13.72;P=0.029;I2异质性为79.5%)。根据分组和元回归结果,国家和基线BMI是可能的异质性来源.根据Begg\和Egger\的测试和漏斗图结果,没有发表偏见。
结论:根据我们的结果,在明显健康的成年人中,较高的循环sRAGE浓度与较低的BMI和WC相关.有必要进行进一步的随机临床试验,以确定因果关系。
BACKGROUND: Several studies have highlighted the possible positive effects of soluble receptor for advanced glycation end products (sRAGE) against obesity. However, due to their inconsistent results, this systematic
review and meta-analysis aimed to quantitatively evaluate and critically
review the results of studies evaluating the relationship between sRAGE with obesity among adult population.
METHODS: In the systematic search, the eligibility criteria were as follows: studies conducted with a cross-sectional design, included apparently healthy adults, adults with obesity, or obesity-related disorders, aged over 18 years, and evaluated the association between general or central obesity indices with sRAGE.
RESULTS: Our systematic search in electronic databases, including PubMed, Scopus, and Embase up to 26 October, 2023 yielded a total of 21,612 articles. After removing duplicates, screening the titles and abstracts, and reading the full texts, 13 manuscripts were included in the final meta-analysis. According to our results, those at the highest category of circulating sRAGE concentration with median values of 934.92 pg/ml of sRAGE, had 1.9 kg/m2 lower body mass index (BMI) (WMD: -1.927; CI: -2.868, -0.986; P < 0.001) compared with those at the lowest category of sRAGE concentration with median values of 481.88 pg/ml. Also, being at the highest sRAGE category with the median values of 1302.3 pg/ml sRAGE, was accompanied with near 6 cm lower waist circumference (WC) (WMD: -5.602; CI: -8.820, -2.383; P < 0.001 with 86.4% heterogeneity of I2) compared with those at the lowest category of sRAGE concentration with median values of 500.525 pg/ml. Individuals with obesity had significantly lower circulating sRAGE concentrations (WMD: -135.105; CI: -256.491, -13.72; P = 0.029; with 79.5% heterogeneity of I2). According to the subgrouping and meta-regression results, country and baseline BMI were possible heterogeneity sources. According to Begg\'s and Egger\'s tests and funnel plots results, there was no publication bias.
CONCLUSIONS: According to our results, higher circulating sRAGE concentrations was associated with lower BMI and WC among apparently healthy adults. Further randomized clinical trials are warranted for possible identification of causal associations.