背景:在患有慢性病的人群中,皮肤自发荧光(SAF),衡量长期荧光晚期糖基化终产物(AGEs)在身体组织中的积累,与血管内皮功能有关,使用流动介导的扩张(FMD)测量。这项研究的主要目的是量化一般人群中成人内皮功能与AGEs组织积累之间的关系,以确定SAF是否可以用作预测内皮早期损伤的标志物。
方法:对125名参与者进行了横断面研究(中位年龄:28.5岁,IQR:24.4-36.0;54%的女性)。通过空腹FMD测量内皮功能。使用AGE阅读器将皮肤AGEs测量为SAF。参与者人体测量,血压,还测量了血液生物标志物。使用多变量回归分析评估关联,并针对显著协变量进行调整。
结果:FMD与SAF(ρ=-0.50,P<0.001)和实际年龄(ρ=-0.51,P<0.001)呈负相关。在多变量分析中,SAF,实际年龄,男性与口蹄疫减少独立相关(B[95%CI];-2.60[-4.40,-0.80];-0.10[-0.16,-0.03];1.40[0.14,2.67],分别),多变量模型调整后的R2=0.31,P<0.001。
结论:更高的皮肤年龄水平,根据苏丹武装部队的测量,与较低的口蹄疫值相关,在一个以年轻人为主的时代,健康人口。此外,老年和男性参与者表现出显著较低的FMD值,与内皮功能受损相对应。这些结果表明,SAF,一个简单而便宜的标记,可用于在出现任何结构性动脉病理生理学或经典心血管疾病风险标志物之前预测内皮损伤。
背景:该研究在澳大利亚新西兰临床试验注册中心(ACTRN12621000821897)进行了前瞻性注册,并以相同的ID号同时进入WHO国际临床试验注册平台。
BACKGROUND: In populations with chronic disease, skin autofluorescence (SAF), a measure of long-term fluorescent advanced glycation end-products (AGEs) accumulation in body tissues, has been associated with vascular endothelial function, measured using flow-mediated dilation (FMD). The primary aim of this study was to quantify the relationship between endothelial function and tissue accumulation of AGEs in adults from the general population to determine whether SAF could be used as a marker to predict early impairment of the endothelium.
METHODS: A cross-sectional study was conducted with 125 participants (median age: 28.5 y, IQR: 24.4-36.0; 54% women). Endothelial function was measured by fasting FMD. Skin AGEs were measured as SAF using an AGE Reader. Participant anthropometry, blood pressure, and blood biomarkers were also measured. Associations were evaluated using multivariable regression analysis and were adjusted for significant covariates.
RESULTS: FMD was inversely correlated with SAF (ρ = -0.50, P < 0.001) and chronological age (ρ = -0.51, P < 0.001). In the multivariable analysis, SAF, chronological age, and male sex were independently associated with reduced FMD (B [95% CI]; -2.60 [-4.40, -0.80]; -0.10 [-0.16, -0.03]; 1.40 [0.14, 2.67], respectively), with the multivariable model adjusted R2 = 0.31, P < 0.001.
CONCLUSIONS: Higher skin AGE levels, as measured by SAF, were associated with lower FMD values, in a predominantly young, healthy population. Additionally, older age and male participants exhibited significantly lower FMD values, corresponding with compromised endothelial function. These results suggest that SAF, a simple and inexpensive marker, could be used to predict endothelial impairment before the emergence of any structural artery pathophysiology or classic cardiovascular disease risk markers.
BACKGROUND: The study was prospectively registered with the Australian New Zealand Clinical Trials Registry (ACTRN12621000821897) and concurrently entered into the WHO International Clinical Trials Registry Platform under the same ID number.