背景:Phenibut是一种在结构上与加巴喷丁和普瑞巴林相似的药物。它可以在网上买到,没有处方,通常作为膳食补充剂或氨基酸衍生物销售。尽管在过去十年中在美国越来越受欢迎,但人们对phenibut的使用知之甚少。目的:阐明服用苯醚的原因,环境,和使用效果。方法:菲尼布报告,加巴喷丁,普瑞巴林的使用是从一个公开的数据库下载的,Erowid.org.使用了一种利用定性内容分析的混合方法。结果:在229份报告中,211人来自男性作者。人们通常在网上购买phenibut,据报道将其用于娱乐,管理医疗或精神问题(主要是失眠,焦虑),作为其他药物(尤其是苯二氮卓类药物)的替代品,管理从另一种物质(包括苯二氮卓类药物,阿片类药物),和/或性能增强。虽然它与普瑞巴林和加巴喷丁共享许多报道的作用,例如抗焦虑,增加健谈,和受损的运动协调,胃肠道不适和镇静的报告更常见的原因是症状.一些人报告说,在限制其使用和管理退出方面存在困难。结论:Phenibut报告表明,Phenibut可能对某些人有一些好处。也使用,然而,具有不利影响的风险,潜在危险的戒断综合征,和上瘾。与非处方加巴喷丁或普瑞巴林没有什么不同,自我药物治疗是使用phenibut的常见动机。医生应继续询问患者使用任何非处方药物,膳食补充剂,或氨基酸衍生物。\“缩写:PWUPh:使用phenibut的人;PWUG:使用加巴喷丁的人;PWUPr:使用普瑞巴林的人。
Background: Phenibut is a drug similar in structure to gabapentin and pregabalin. It is available online without prescription, often marketed as a dietary supplement or amino acid derivative. Little is known about phenibut use despite its increased popularity in the United States over the last decade.Objective: To clarify reasons for taking phenibut, circumstances, and effects of use.Methods:
Reports of phenibut, gabapentin, and pregabalin use were downloaded from a publicly-available database, Erowid.org. A mixed methods approach utilizing qualitative content analysis was used.Results: Of 229
reports, 211 were from male authors. People usually purchased phenibut online and reportedly used it for recreation, to manage a medical or psychiatric problem (primarily insomnia, anxiety), as a substitute for other drugs (especially benzodiazepines), to manage withdrawal from another substance (including benzodiazepines, opioids), and/or for performance enhancement. While it shared many reported effects with pregabalin and gabapentin such as anxiolysis, increased talkativeness, and impaired motor coordination,
reports of gastrointestinal distress and sedation were more commonly attributed to phenibut. Several people reported difficulty in restricting their use and managing withdrawal.Conclusions: Phenibut
reports suggest that phenibut may have some benefits for some people. Use also, however, carries risks of adverse effects, a potentially dangerous withdrawal syndrome, and addiction. Not dissimilar to unprescribed gabapentin or pregabalin, self-medication is a common motive for phenibut use. Physicians should continue to ask their patients about use of any non-prescribed medications, dietary supplements, or \"amino acid derivatives.\"Abbreviation: PWUPh: people who use phenibut; PWUG: people who use gabapentin; PWUPr: people who use pregabalin.