UNASSIGNED:实施HBV筛查和治疗的策略对于实现HBV消除至关重要,但在撒哈拉以南非洲(sSA)尚未得到充分评估。
UNASSIGNED:我们评估了在3种现实环境中进行屏幕和治疗干预的可行性(社区,workplace,和医院)在塞内加尔。成人参与者使用快速HBsAg点护理测试进行筛查。与护理相关的比例,完成临床分期的比例(丙氨酸转氨酶[ALT],病毒载量,和FibroScan®),并比较3个干预组的符合治疗条件的比例。
UNASSIGNED:在2013-2016年,共有3,665人在社区(n=2,153)和工作场所(n=1,512)进行了HBsAg筛查;199/2,153(9.2%)和167/1,512(11%)在社区和工作场所均为HBsAg阳性,分别。在医院设置(门诊),638名HBsAg阳性参与者参加了研究。所有受感染的参与者都是幼稚治疗。社区与护理的联系相似(69.9%),以工作场所为基础(69.5%),和基于医院的干预措施(72.6%,p=0.617)。HBV感染的参与者成功地连接到护理,47.5%(66/139)获得了完整的临床分期,59.5%(69/116),71.1%(329/463)来自社区,工作场所,还有医院,分别(p<0.001)。符合治疗条件(EASL标准)的比例因社区而异(9.1%),工作场所-(30.4%),和医院设置(17.6%,p=0.007)。抗病毒治疗的可接受性,坚持,一年的安全性非常好。
UNASSIGNED:HBV筛查和治疗干预措施在塞内加尔的非医院和医院环境中是可行的。然而,由于获得完整的临床分期的机会有限,因此连续的护理并不理想。在sSA中,迫切需要改善获得诊断服务的机会。
未经评估:乙型肝炎感染在塞内加尔高度流行。感染筛查可以在医院外进行,在社区或工作场所。然而,在塞内加尔,乙型肝炎连续治疗并不理想,需要简化以扩大诊断和治疗覆盖率.
UNASSIGNED: Strategies to implement HBV screening and treatment are critical to achieve HBV elimination but have been inadequately evaluated in sub-Saharan Africa (sSA).
UNASSIGNED: We assessed the feasibility of screen-and-treat interventions in 3 real-world settings (community, workplace, and hospital) in Senegal. Adult participants were screened using a rapid HBsAg point-of-care test. The proportion linked to care, the proportion who had complete clinical staging (alanine transaminase [ALT], viral load, and FibroScan®), and the proportion eligible for treatment were compared among the 3 intervention groups.
UNASSIGNED: In 2013-2016, a total of 3,665 individuals were screened for HBsAg in the community (n = 2,153) and in workplaces (n = 1,512); 199/2,153 (9.2%) and 167/1,512 (11%) were HBsAg-positive in the community and workplaces, respectively. In the hospital setting (outpatient clinics), 638 HBsAg-positive participants were enrolled in the study. All infected participants were treatment naïve. Linkage to care was similar among community-based (69.9%), workplace-based (69.5%), and hospital-based interventions (72.6%, p = 0.617). Of HBV-infected participants successfully linked to care, full clinical staging was obtained in 47.5% (66/139), 59.5% (69/116), and 71.1% (329/463) from the community, workplaces, and hospitals, respectively (p <0.001). The proportion eligible for treatment (EASL criteria) differed among community- (9.1%), workplace- (30.4%), and hospital-based settings (17.6%, p = 0.007). Acceptability of antiviral therapy, adherence, and safety at 1 year were very good.
UNASSIGNED: HBV screen-and-treat interventions are feasible in non-hospital and hospital settings in Senegal. However, the continuum of care is suboptimal owing to limited access to full clinical staging. Improvement in access to diagnostic services is urgently needed in sSA.
UNASSIGNED: Hepatitis B infection is highly endemic in Senegal. Screening for infection can be done outside hospitals, in communities or workplaces. However, the hepatitis B continuum of care is suboptimal in Senegal and needs to be simplified to scale-up diagnosis and treatment coverage.