■熊果酸(UA)已用于替代医学数十年,人们对它的药用特性很感兴趣。尽管兴趣增加,尚未进行详细的长期毒性研究。这项研究的目的是确定UA对临床化学的长期毒性作用,血液学,凝血,病理学/形态学,大鼠的行为和运动技能。
■通过将UA溶解在Milli-Q水中的0.1%吐温80和0.5%羟丙基甲基纤维素的混合物中来制备溶液。对照组接收了车辆,测试组通过口服管饲法接受高达1000mg/kg/天的剂量。将该溶液连续90天给予雄性和雌性(Han-Wistar)大鼠。
■UA没有造成任何死亡,所有测试剂量的异常体重或异常病理。除此之外,在行为上没有观察到毒理学变化,神经毒性,凝血,与UA管理相关的血液学或临床化学。
■这项研究表明,连续90天口服UA不会导致任何剂量的毒性作用。因此,UA的NOAEL可能高于1000mg/kg/天。
UNASSIGNED: Ursolic acid (UA) has been used in alternative medicine for decades, and there has been a great interest in its medicinal properties. Despite this increased interest, a detailed long-term toxicity
study has not been performed. The objective of this
study was to determine the long-term toxic effect of UA on clinical chemistry, haematology, coagulation, pathology/morphology, behaviour and motor skills in rats.
UNASSIGNED: A solution was made by dissolving UA in a mixture of 0.1% Tween 80 and 0.5% hydroxypropyl methylcellulose in Milli-Q Water. The control group received the vehicle, and the test groups received a dose up to 1000 mg/kg/day via oral gavage. The solution was administered to both male and female (Han-Wistar) rats for 90 consecutive days.
UNASSIGNED: UA did not cause any deaths, abnormal body weights or abnormal pathology at all test doses. In addition to that, no toxicological changes were observed in behaviour, neurotoxicity, coagulation, haematology or clinical chemistry that are related to the administration of UA.
UNASSIGNED: This
study indicates that oral dosing of UA for 90 consecutive days does not lead to toxic effects at any of the doses. Therefore, the NOAEL for UA is likely to be higher than 1000 mg/kg/day.