PDF(Pubmed)
Abstract：
The current work clarifies the negative effects of excess exposure to boric acid (H3BO3) as a boron-containing compound on rats and the possible ameliorative effect of melatonin (MEL). Forty rats were equally divided into 5 groups as follows: group 1 was treated as control while groups 2, 3, 4 and 5 were orally administered corn oil (0.5 ml), H3BO3 (1330 mg/kg BW), MEL (10 mg/kg BW) and H3BO3 + MEL for 28 consecutive days, respectively. At the end of the experiment, blood was sampled for biochemical and hematological analysis and tissues were collected for histopathological examination. The obtained results demonstrated that the exposure to H3BO3 induced hepatorenal dysfunctions, alterations in bone-related minerals and hormones levels, prostaglandin E2 as inflammatory mediator and hematological indices. H3BO3 induced histological alterations in the liver, kidneys, bone and skin. The co-administration of MEL with H3BO3 resulted in a significant improvement in most of the measured parameters and restoration of morpho-functional state of different organs compared to the H3BO3 group. In conclusion, the study clearly demonstrated that H3BO3- induced various adverse effects and that melatonin may be beneficial in a partial mitigating the H3BO3 and may represent a novel approach in the counteracting its toxicity.
摘要：
目前的工作阐明了过量暴露于含硼化合物硼酸（H3BO3）对大鼠的负面影响以及褪黑激素（MEL）的可能改善作用。将40只大鼠平均分为以下5组：第1组作为对照组，第2、3、4和5组口服玉米油（0.5ml），H3BO3（1330mg/kgBW），MEL（10mg/kgBW）和H3BO3+MEL连续28天，分别。实验结束时,采集血液进行生化和血液学分析,收集组织进行组织病理学检查.获得的结果表明，暴露于H3BO3引起肝肾功能障碍，骨相关矿物质和激素水平的改变，前列腺素E2作为炎症介质和血液学指标。H3BO3诱导肝脏组织学改变，肾脏，骨头和皮肤。与H3BO3组相比，MEL与H3BO3的共同给药导致大多数测量参数的显着改善和不同器官的形态功能状态的恢复。总之,该研究清楚地表明,H3BO3-诱导了各种不良反应,褪黑素可能有助于部分缓解H3BO3,并且可能代表了抵消其毒性的新方法.
