Energy metabolism

能量代谢
  • 文章类型: Journal Article
    呼吸测定法是了解整个动物能量和水平衡与环境关系的重要工具。因此,在过去十年中,使用呼吸测量法的研究越来越多,因此需要可靠的报告和数据共享,以进行有效的传播和研究综合。我们提供了五个关键部分的清单指南,以促进透明度,再现性,呼吸测定研究的可重复性:1)材料,设置,管道,2)主题条件/维护,3)测量条件,4)数据处理,5)数据报告和统计,每个都有解释和例子研究。报告和数据可用性的透明度在多个方面都有好处。作者可以使用这个清单来设计和报告他们的研究,审稿人和编辑可以使用清单来评估他们审稿的报告质量。改进的报告标准将提高初级研究的价值,并将极大地促进开展更高质量的研究综合以解决生态和进化理论的能力。
    Respirometry is an important tool for understanding whole-animal energy and water balance in relation to the environment. Consequently, the growing number of studies using respirometry over the last decade warrants reliable reporting and data sharing for effective dissemination and research synthesis. We provide a checklist guideline on five key sections to facilitate the transparency, reproducibility, and replicability of respirometry studies: 1) materials, set up, plumbing, 2) subject conditions/maintenance, 3) measurement conditions, 4) data processing, and 5) data reporting and statistics, each with explanations and example studies. Transparency in reporting and data availability has benefits on multiple fronts. Authors can use this checklist to design and report on their study, and reviewers and editors can use the checklist to assess the reporting quality of the manuscripts they review. Improved standards for reporting will enhance the value of primary studies and will greatly facilitate the ability to carry out higher quality research syntheses to address ecological and evolutionary theories.
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  • 文章类型: Journal Article
    而身体活动,睡眠和久坐行为几乎总是被独立考虑,它们应该被视为人类的综合行为。24小时运动方法提出了对这些行为的伴随考虑,以促进整体健康。这些行为不仅影响能量消耗,但它们也被证明会分别影响能量摄入,在考虑24h运动方法下这些运动行为的整体整合时,应该进一步探索。在评估了满足24小时运动和饮食建议的患病率后,这篇综述总结了有关24小时运动指南与饮食习惯之间关联的现有证据(使用PubMed/MEDLINE索引的英文出版物).总之,结果清楚地表明了同时推广24小时指南的有益影响,强调受尊重的运动建议数量越多,更好的饮食行为在儿童和成人。重要的是,我们的研究结果指出,强调必须达到久坐的准则,以更好的饮食习惯。运动和饮食行为显得密切相关,给一个建议可能会影响另一个。将24小时运动与饮食指南相结合可能比在公共卫生策略中单独推广它们更有效。
    While physical activity, sleep and sedentary behaviors are almost always considered independently, they should be considered as integrated human behaviors. The 24 h Movement approach proposes a concomitant consideration of these behaviors to promote overall health. Not only do these behaviors impact energy expenditure, but they have also been shown to separately impact energy intake, which should be further explored when considering the entire integration of these movement behaviors under the 24 h movement approach. After an evaluation of the prevalence of meeting the 24 h Movement and dietary recommendations, this review summarizes the available evidence (using English publications indexed in PubMed/MEDLINE) regarding the association between the 24 h Movement Guidelines and eating habits. Altogether, the results clearly show the beneficial impact of promoting the 24 h guidelines simultaneously, highlighting that the higher the number of respected movement recommendations, the better eating behaviors in both children and adults. Importantly, our results point out the importance of emphasizing the need to reach sedentary guidelines for better eating habits. Movement and dietary behaviors appear closely related, and giving recommendations on one might impact the other. Combining the 24 h Movement with dietary Guidelines might be more efficient than promoting them separately in public health strategies.
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  • 文章类型: Systematic Review
    背景:患有肥胖症的重症患者具有独特而复杂的营养需求,与临床实践指南在推荐的能量目标方面存在冲突。本系统评价的目的是1)描述文献中报道的测量的静息能量消耗(mREE);2)当肥胖的危重患者无法使用间接量热法时,使用欧洲(ESPEN)和美国(ASPEN)指南建议将mREE与预测的能量目标进行比较。
    方法:该方案是事先注册的,文献一直搜索到3月17日,2022年。如果原始研究使用间接量热法报告肥胖危重患者(BMI≥30kg/m2)的mREE,则将其包括在内。根据主要出版物,使用平均值±标准偏差或中位数[四分位数范围]报告组水平mREE数据。在有个别患者数据的情况下,Bland-Altman分析用于评估指南建议与mREE目标之间的平均偏差(95%的一致性限制)(即BMI30-50,11-14kcal/kg实际体重与70%mREE相比的ASPEN和ESPEN20-25kcal/kg调整体重与100%mREE相比)。准确性通过mREE目标的±10%内的估计值的百分比(%)进行评估。
    结果:在搜索了8019篇文章之后,包括24项研究。mREE范围为1607±385至2919[2318-3362]kcal和12-32kcal/实际体重。对于11-14千卡/千克的ASPEN建议,平均偏差为-18%(-50%至+13%)和4%(-36%至+44%)。分别(n=104)。对于ESPEN建议20-25千卡/千克,偏差为-22%(-51%至+7%)和-4%(-43%至+34%),被观察到,分别(n=114)。指南建议能够在30%-39%的情况下(实际11-14kcal/kg)和15%-45%的情况下(调整后20-25kcal/kg)准确预测mREE目标,对于ASPEN和ESPEN建议,分别。
    结论:肥胖危重患者的能量消耗是可变的。使用ASPEN和ESPEN临床指南中推荐的预测方程生成的能量目标与mREE的一致性较差,并且通常无法在mREE的±10%内准确预测。最常见的是低估了能源需求。
    Critically ill patients with obesity have unique and complex nutritional needs, with clinical practice guidelines conflicting regarding recommended energy targets. The aim of this systematic review was to 1) describe measured resting energy expenditure (mREE) reported in the literature and; 2) compare mREE to predicted energy targets using the European (ESPEN) and American (ASPEN) guideline recommendations when indirect calorimetry is not available in critically ill patients with obesity.
    The protocol was registered apriori and literature was searched until 17th March, 2022. Original studies were included if they reported mREE using indirect calorimetry in critically ill patients with obesity (BMI≥30 kg/m2). Group-level mREE data was reported as per the primary publication using mean ± standard deviation or median [interquartile range]. Where individual patient data was available, Bland-Altman analysis was used to assess mean bias (95% limits of agreement) between guideline recommendations and mREE targets (i.e. ASPEN for BMI 30-50, 11-14 kcal/kg actual weight compared to 70% mREE and ESPEN 20-25 kcal/kg adjusted weight compared to 100% mREE). Accuracy was assessed by the percentage (%) of estimates within ±10% of mREE targets.
    After searching 8019 articles, 24 studies were included. mREE ranged from 1607 ± 385 to 2919 [2318-3362]kcal and 12-32kcal/actual body weight. For the ASPEN recommendations of 11-14 kcal/kg, a mean bias of -18% (-50% to +13%) and 4% (-36% to +44%) was observed, respectively (n = 104). For the ESPEN recommendations 20-25 kcal/kg, a bias of -22% (-51% to +7%) and -4% (-43% to +34%), was observed, respectively (n = 114). The guideline recommendations were able to accurately predict mREE targets on 30%-39% occasions (11-14 kcal/kg actual) and 15%-45% occasions (20-25 kcal/kg adjusted), for ASPEN and ESPEN recommendations, respectively.
    Measured energy expenditure in critically ill patients with obesity is variable. Energy targets generated using predictive equations recommended in both the ASPEN and ESPEN clinical guidelines have poor agreement with mREE and are frequently not able to accurately predict within ±10% of mREE, most commonly underestimating energy needs.
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  • 文章类型: Journal Article
    使用原始加速度或机器学习等新颖分析方法(“新颖方法”)分析加速度计数据的方法的激增超过了其在实践中的实现。这可能是由于缺乏可访问性,要么是因为作者没有提供他们开发的模型,要么是因为这些模型在作为补充材料包含时很难找到。此外,当提供对模型的访问时,作者可能不包括如何使用模型的示例数据或说明。这进一步阻碍了其他研究人员的使用,特别是那些不是统计或编写计算机代码的专家。目标:我们创建了一个分析加速度计数据的新方法库,用于估算能量消耗和/或身体活动强度,以及一个框架和报告指南,以指导未来的工作。方法:方法是从最近的范围审查中确定的。可用代码,模型,样本数据,和指令被编译或创建。主要结果:63种方法托管在存储库中,在学龄前儿童中(n=6),儿童/青少年(n=20),和成年人(n=42),使用髋关节(n=45),手腕(n=25),大腿(n=4),胸部(n=4),脚踝(n=6),其他(n=4),或监测磨损位置的组合(n=9)。在R中实现了15个模型,虽然提供了48个作为切入点,方程,或决策树。意义:开发的工具应有助于使用和开发分析加速度计数据的新方法,从而提高研究之间的数据一致性和一致性。未来的进步可能涉及包括作者未链接到原始发表的文章或识别活动类型的模型。
    The proliferation of approaches for analyzing accelerometer data using raw acceleration or novel analytic approaches like machine learning (\'novel methods\') outpaces their implementation in practice. This may be due to lack of accessibility, either because authors do not provide their developed models or because these models are difficult to find when included as supplementary material. Additionally, when access to a model is provided, authors may not include example data or instructions on how to use the model. This further hinders use by other researchers, particularly those who are not experts in statistics or writing computer code.Objective: We created a repository of novel methods of analyzing accelerometer data for the estimation of energy expenditure and/or physical activity intensity and a framework and reporting guidelines to guide future work.Approach: Methods were identified from a recent scoping review. Available code, models, sample data, and instructions were compiled or created.Main Results: Sixty-three methods are hosted in the repository, in preschoolers (n = 6), children/adolescents (n = 20), and adults (n = 42), using hip (n = 45), wrist (n = 25), thigh (n = 4), chest (n = 4), ankle (n = 6), other (n = 4), or a combination of monitor wear locations (n = 9). Fifteen models are implemented in R, while 48 are provided as cut-points, equations, or decision trees.Significance: The developed tools should facilitate the use and development of novel methods for analyzing accelerometer data, thus improving data harmonization and consistency across studies. Future advances may involve including models that authors did not link to the original published article or those which identify activity type.
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  • 文章类型: Journal Article
    背景:评估(1)临床实践指南(CPG)的方法学质量,该指南使用AGREEII工具为危重成人提供营养护理,以及(2)CPG建议使用AGREE-REX工具确定能量消耗。方法:由专业学会或学术团体进行CPG,旨在指导危重病成年人的营养护理,使用了系统的文献检索并对证据进行了评级。从2011年1月至2022年1月19日检索了四个数据库和灰色文献。五名研究人员评估了CPG的方法学质量以及针对能量消耗确定的建议。计算AGREEII的缩放域得分,并计算AGREE-REX的缩放总分。数据以中位数(四分位间距)表示。结果:共纳入11个CPGs。AGREEII得分最高的领域是表达的清晰度(82%[76-87%])以及范围和目的(78%[66-83%])。得分最低的领域是适用性(37%[32-42%])和利益相关者参与(46%[33-51%])。八个(73%)CPG提供了有关能量消耗确定的建议;总体得分较低(37%[36-40%])和各个领域。结论:危重患者的营养CPG是使用系统方法开发的,但缺乏关键利益相关者的参与和支持应用的指导。能耗确定建议的质量较低。
    Background: To evaluate the methodological quality of (1) clinical practice guidelines (CPGs) that inform nutrition care in critically ill adults using the AGREE II tool and (2) CPG recommendations for determining energy expenditure using the AGREE-REX tool. Methods: CPGs by a professional society or academic group, intended to guide nutrition care in critically ill adults, that used a systematic literature search and rated the evidence were included. Four databases and grey literature were searched from January 2011 to 19 January 2022. Five investigators assessed the methodological quality of CPGs and recommendations specific to energy expenditure determination. Scaled domain scores were calculated for AGREE II and a scaled total score for AGREE-REX. Data are presented as medians (interquartile range). Results: Eleven CPGs were included. Highest scoring domains for AGREE II were clarity of presentation (82% [76-87%]) and scope and purpose (78% [66-83%]). Lowest scoring domains were applicability (37% [32-42%]) and stakeholder involvement (46% [33-51%]). Eight (73%) CPGs provided recommendations relating to energy expenditure determination; scores were low overall (37% [36-40%]) and across individual domains. Conclusions: Nutrition CPGs for critically ill patients are developed using systematic methods but lack engagement with key stakeholders and guidance to support application. The quality of energy expenditure determination recommendations is low.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    There has been substantial progress in the knowledge of exercise and type 1 diabetes, with the development of guidelines for optimal glucose management. In addition, an increasing number of people living with type 1 diabetes are pushing their physical limits to compete at the highest level of sport. However, the post-exercise recovery routine, particularly with a focus on sporting performance, has received little attention within the scientific literature, with most of the focus being placed on insulin or nutritional adaptations to manage glycaemia before and during the exercise bout. The post-exercise recovery period presents an opportunity for maximising training adaption and recovery, and the clinical management of glycaemia through the rest of the day and overnight. The absence of clear guidance for the post-exercise period means that people with type 1 diabetes should either develop their own recovery strategies on the basis of individual trial and error, or adhere to guidelines that have been developed for people without diabetes. This Review provides an up-to-date consensus on post-exercise recovery and glucose management for individuals living with type 1 diabetes. We aim to: (1) outline the principles and time course of post-exercise recovery, highlighting the implications and challenges for endurance athletes living with type 1 diabetes; (2) provide an overview of potential strategies for post-exercise recovery that could be used by athletes with type 1 diabetes to optimise recovery and adaptation, alongside improved glycaemic monitoring and management; and (3) highlight the potential for technology to ease the burden of managing glycaemia in the post-exercise recovery period.
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  • 文章类型: Letter
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  • 文章类型: Journal Article
    重症卒中患者静息能量消耗(REE)的扰动定义不明确,当间接量热法(IC)无法估算每日能量需求时,指南建议基于体重的给药。我们旨在确定与指南推荐的IC目标相比,指南推荐的基于体重的给药是否提供足够的能量需求。
    收集了进入神经重症监护病房的卒中患者的IC数据。我们将低体重给药(25kcal/kg)和高(30kcal/kg)与ICREE目标进行了比较。随后,我们分析了卒中亚型对这些测量结果差异的影响.
    进行了72项代谢研究(45.1%脑出血[ICH],18.3%动脉瘤性蛛网膜下腔出血[aSAH],和36.6%的急性缺血性卒中[AIS])。能源需求,使用低体重组估计,显著低于ICREE目标(1496千卡/天[IQR,1224-1850]vs1770千卡/天[IQR,1400-2150];P=.003)。基于高体重的群体能量测量与ICREE目标相似(1806千卡/天[IQR,1530-2236]vs1770千卡/天;P=.343)。亚组分析表明,在ICH和aSAH中,基于低权重的计算值明显低于IC,但它们在AIS上相似(分别为P≤.001、.016和.078)。线性回归分析表明,高度,出血性卒中亚型与IC相关(分别为P≤.001,.024和.051).
    重症卒中患者基于体重的能量需求估计与指南推荐的IC估计之间存在重要差异。基于低体重的REE计算低估了ICH和aSAH患者的能量需求。
    Perturbations in resting energy expenditure (REE) among critically ill stroke patients are ill defined, and guidelines recommend weight-based dosing when indirect calorimetry (IC) is not feasible to estimate daily energy requirements. We aimed to determine whether guideline-recommended weight-based dosing provides adequate energy requirements compared with guidelines recommended IC target.
    IC data was collected on stroke patients admitted to a neurocritical care unit. We compared low-weight-based dosing (25 kcal/kg) and high (30 kcal/kg) with the IC REE target. Subsequently, we analyzed the effect of stroke subtype on the differences among these measurements.
    Seventy-two metabolic studies were performed (45.1% intracerebral hemorrhage [ICH], 18.3% aneurysmal subarachnoid hemorrhage [aSAH], and 36.6% acute ischemic stroke [AIS]). Energy needs, estimated using low-weight-based group, were significantly lower than IC REE target (1496 kcal/day [IQR, 1224-1850] vs 1770 kcal/day [IQR, 1400-2150]; P = .003). High weight-based group energy measurements were similar to IC REE target (1806 kcal/day [IQR, 1530-2236] vs 1770 kcal/day; P = .343). Subgroup analysis showed that low-weight-based calculations were significantly lower than those of IC in ICH and aSAH, but they were similar in AIS (P ≤ .001, .016, and .078, respectively). Linear regression analysis showed that weight, height, and hemorrhagic stroke subtype were associated with IC (P ≤ .001, .024, and .051, respectively).
    Important differences between weight-based estimation of energy needs and guideline-recommended IC estimation exist for critically ill stroke patients. Low-weight-based calculations of REE underestimate energy needs in ICH and aSAH patients.
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  • 文章类型: Journal Article
    Pedelecs (e-bikes with electrical support up to 25 km·h-1) are important in active transportation. Yet, little is known about physiological responses during their everyday use. We compared daily pedelec (P) and bicycle (B) use to determine if pedelecs are a suitable tool to enhance physical activity. In 101 employees, cycling duration and intensity, heart rate (HR) during P and B were recorded via a smartphone app. Each recording period was a randomized crossover design and lasted two weeks. The ride quantity was higher in P compared to B (5.3 ± 4.3 vs. 3.2 ± 4.0 rides·wk-1; p < 0.001) resulting in a higher total cycling time per week for P (174 ± 146 min·wk-1) compared to B (99 ± 109 min·wk-1; p < 0.001). The mean HR during P was lower than B (109 ± 14 vs. 118 ± 17 bpm; p < 0.001). The perceived exertion was lower in P (11.7 ± 1.8 vs. 12.8 ± 2.1 in B; p < 0.001). The weekly energy expenditure was higher during P than B (717 ± 652 vs. 486 ± 557 metabolic equivalents of the task [MET]·min·wk-1; p < 0.01). Due to a sufficient HR increase in P, pedelecs offer a more active form of transportation to enhance physical activity.
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