双酚A(BPA),一种有毒的内分泌干扰物,在环境中广泛分布,BPA暴露对人类健康结果的影响是一个关键问题。这项研究的目的是对已发表的荟萃分析进行综述,调查双酚A暴露与人类相关健康结果之间的关联。从成立到2023年7月12日,从三个电子数据库中检索了相关报告,包括PubMed,ScienceDirect,和Embase。我们的综述包括系统评价和荟萃分析的报告,这些报告调查了双酚A暴露与人类健康结果之间的关联。我们的审查共包括14份报告。调查了与暴露BPA相关的几种人类健康结果,包括产妇产前健康,婴儿健康,过敏性疾病,肾病,代谢综合征,多囊卵巢综合征,青春期较早,炎症和免疫反应,新生儿的甲状腺功能。在这些健康结果中,BPA暴露与多种人类健康结果相关,包括早产。过敏性疾病,肾病,多囊卵巢综合征,肥胖,2型糖尿病,心血管疾病,高血压,以及炎症和免疫反应(C反应蛋白和白细胞介素-6)。这些结果表明,双酚A暴露严重影响了人类健康。为了保护人类健康,世界卫生组织应该对双酚A制定有意义的法规,以减少环境污染。
Bisphenol A (BPA), a toxic endocrine disruptor, is widely distributed in the environment, and the effects of BPA exposure on human health outcomes are a critical issue. The objective of this study was to perform an umbrella
review of published meta-analyses investigating the associations between BPA exposure and human-related health outcomes. The relevant reports were searched from three electronic databases from inception to July 12, 2023 including PubMed, ScienceDirect, and Embase. The reports that were systematic reviews with meta-analyses investigating the associations between BPA exposure and human health outcomes were included in our
review. A total of 14 reports were included in our
review. Several human health outcomes related to exposure BPA were investigated including maternal prenatal health, infant health, allergic diseases, kidney disease, metabolic syndromes, polycystic ovary syndrome, earlier puberty, inflammation and immune responses, and thyroid function in neonates. Among these health outcomes, BPA exposure was associated with multiple human health outcomes including preterm birth, allergic diseases, kidney disease, polycystic ovarian syndrome, obesity, type 2 diabetes, cardiovascular disease, hypertension, and inflammation and immune responses (C-reactive protein and interleukin-6). These results showed that BPA exposure has seriously affected human health. To protect human health, World Health Organization should develop meaningful regulations on BPA to decrease the environmental contamination.