全球正在努力改善对内分泌干扰化学品的评估和了解。认识到它们对人类健康和环境的影响已经引起了该领域的关注和研究。各种利益相关者,包括科学家,监管机构,政策制定者,和行业代表,正在合作开发评估这些破坏者的可靠方法和指南。这些努力的一个关键方面是制定标准化的测试方案和指南,旨在提供一致和可靠的方法来识别和表征内分泌干扰物。在评估化学物质潜在的内分泌干扰活性时,没有一个单一的测试能够检测所有相关的内分泌干扰剂。测试电池方法旨在降低具有潜在毒性的化合物的假阴性结果的风险。因此,证据权重方法对于内分泌干扰物评估是必要的。这种方法考虑了来自多个来源的各种类型的数据,评估整体实力,一致性,证据的可靠性。经合组织的指导方针因其科学严谨而备受推崇,透明度,和基于共识的发展进程。探索和开发能够有效评估与潜在内分泌干扰物相关风险的新方法至关重要。将这些方法纳入全面的证据权重框架将加强风险评估,并有助于就这些物质的监管和管理做出明智的决定。确保保护人类健康和环境免受其不利影响。
Efforts are being made globally to improve the evaluation and understanding of endocrine-disrupting chemicals. Recognition of their impact on human health and the environment has stimulated attention and research in this field. Various stakeholders, including scientists, regulatory agencies, policymakers, and industry representatives, are collaborating to develop robust methodologies and
guidelines for assessing these disruptors. A key aspect of these efforts is the development of standardized testing protocols and
guidelines that aim to provide consistent and reliable methods for identifying and characterizing endocrine disruptors. When evaluating the potential endocrine-disrupting activity of chemicals, no single test is capable of detecting all relevant endocrine-disrupting agents. The test battery approach is designed to reduce the risk of false negative results for compounds with toxic potential. A weight-of-evidence approach is therefore necessary for endocrine disruptor evaluation. This approach considers various types of data from multiple sources, assessing the overall strength, consistency, and reliability of the evidence. OECD
guidelines are highly regarded for their scientific rigor, transparency, and
consensus-based development process. It is crucial to explore and develop new methodologies that can effectively evaluate the risks associated with potential endocrine disruptors. Integrating these methods into a comprehensive weight-of-evidence framework will enhance risk assessments and facilitate informed decisions regarding the regulation and management of these substances, ensuring the protection of human health and the environment from their adverse effects.