PDF(Pubmed)
Abstract：
Endocrine disruptor chemicals (EDCs) can have a harmful effect on the human body\'s endocrine system and thus adversely affect the development, reproduction, neurological, cardiovascular, and immune systems and metabolism in humans and wildlife. According to the World Health Organization, EDCs are mostly man-made and found ubiquitously in our daily lives, notably in pesticides, metals, and additives or contaminants in food and personal care products. Human exposure occurs through ingestion, inhalation, and dermal contact. Bisphenol A (BPA) is a proven EDC capable of mimicking or blocking receptors and altering hormone concentrations and metabolism. Although consumed in low doses, it can stimulate cellular responses and affect the body\'s functions. In humans, exposure to BPA has been correlated with the onset or development of several diseases. This literature review aimed to verify the effects of BPA on human male infertility using the most recently published literature. Thus, this review allowed us to conclude that this compound seems to have harmful effects on human male fertility, causing changes in hormonal and semen characteristics. However, these conclusions lack more robust and reproducible scientific studies. Even so, and since male infertility prevalence is increasing, preventive measures must be taken to ensure male fertility.
摘要：
内分泌干扰物（EDCs）可能对人体的内分泌系统产生有害影响，从而对发育产生不利影响。繁殖，神经学,心血管,人类和野生动物的免疫系统和新陈代谢。根据世界卫生组织，EDC大多是人造的，在我们的日常生活中无处不在，特别是在杀虫剂中，金属，以及食品和个人护理产品中的添加剂或污染物。人体暴露是通过摄入发生的，吸入,和皮肤接触。双酚A（BPA）是一种经证实的EDC，能够模拟或阻断受体并改变激素浓度和代谢。虽然在低剂量下食用，它可以刺激细胞反应，影响身体的功能。在人类中,BPA的暴露与几种疾病的发生或发展有关。本文献综述旨在使用最近发表的文献来验证BPA对人类男性不育的影响。因此，这篇评论让我们得出结论，这种化合物似乎对人类男性生育能力有有害影响，导致荷尔蒙和精液特征的变化。然而,这些结论缺乏更可靠和可重复的科学研究。即便如此,由于男性不育的患病率正在增加，必须采取预防措施以确保男性生育能力。
