背景:离子电渗疗法(IPT)是一种非侵入性技术,它使用电脉冲将带电分子输送到皮肤中以进行受控和靶向的药物输送。IPT已被探索为Peyronie病(PD)的非侵入性治疗选择,但是目前这方面的文献仍然很少。
目的:我们旨在系统回顾当前有关IPT在PD管理中应用的文献,以提供对该主题的全面评估和整体展望。
方法:在以下数据库中实施了全面的搜索策略,以检索研究文章:PubMed(MEDLINE),Scopus,和WebofScience。谷歌学者也被手动搜索。根据预定义的纳入标准,将搜索结果导入Rayyan参考管理中进行评估。文章的质量由适当的JBI检查表(即,根据研究设计),并使用JBI推荐等级对证据进行分级.
结果:系统搜索产生451种出版物,其中11项符合本系统审查的标准。结果表明,IPT,通常使用维拉帕米和地塞米松,在治疗PD方面已显示出有希望的结果。这些方法可以减轻疼痛,斑块大小,和阴茎弯曲,同时改善性功能和生活质量,无严重不良事件。然而,大多数研究有中等到低质量,表明对某种健康管理策略的推荐力度较弱。
结论:根据现有文献,目前没有足够的证据支持使用IPT来管理PD.将其放在研究的最前沿可以进一步促进PD的管理选择,考虑到它的治疗潜力。
BACKGROUND: Iontophoresis therapy (IPT) is a noninvasive technique that uses electrical impulses to deliver charged molecules into the skin for controlled and targeted drug delivery. IPT has been explored as a noninvasive treatment option for Peyronie\'s disease (PD), but the current literature in this regard is still scarce.
OBJECTIVE: We aimed to systematically review the current literature on the application of IPT in the management of PD to provide a comprehensive evaluation and holistic outlook on the subject.
METHODS: A comprehensive search strategy was implemented in the following databases to retrieve research articles: PubMed (MEDLINE), Scopus, and Web of Science. Google Scholar was also manually searched. The search results were imported into Rayyan reference management for assessment based on the predefined inclusion criteria. The quality of the articles was evaluated by the proper JBI checklist (ie, per the study design), and the JBI grades of recommendation were used for grading the evidence.
RESULTS: A systematic search yielded 451 publications, 11 of which met the criteria to be included in this systematic review. The results demonstrated that IPT, usually with verapamil and dexamethasone, has shown promising results in treating PD. These methods can reduce pain, plaque size, and penile curvature while improving sexual function and quality of life with no serious adverse events. However, most studies had moderate to low quality, indicating a weak recommendation for a certain health management strategy.
CONCLUSIONS: Based on the extant literature, there is currently insufficient evidence to support the use of IPT for the management of PD. Placing it in the forefront of research can facilitate the management choices for PD even further, given its therapeutic potential.