牛皮癣会增加患各种癌症的风险,包括结肠癌.银屑病和癌症共同发生的发病机制尚不清楚。本研究旨在通过生物信息学分析来分析银屑病合并癌症的发病机制。从GEO数据库下载来自银屑病的皮肤组织数据(GSE117239)和来自结肠癌的肠组织数据(GSE44076)。确定了一千二百九十六个常见的差异表达基因和688个常见的牛皮癣和结肠癌共享基因,分别,采用LIMMAR包和加权基因共表达网络分析(WGCNA)方法。GO和KEGG富集分析的结果主要与细胞周期的生物过程有关。选择了13个hub基因,包括AURKA,DLGAP5,NCAPG,CCNB1,NDC80,BUB1B,TTK,CCNB2,AURKB,TOP2A,ASPM,BUB1和KIF20A。这些hub基因有很高的诊断价值,其中大部分与活化的CD4T细胞呈正相关。还预测了三个枢纽转录因子(TF):E2F1、E2F3和BRCA1。这些hub基因和hubTF在各种癌症中高度表达。此外,预测了251种药物,其中一些与现有的牛皮癣或结肠癌治疗药物重叠。本研究通过生物信息学分析揭示了银屑病和癌症的一些遗传机制。这些枢纽基因,集线器TFs,和预测的药物可能为进一步研究机制和治疗提供新的视角。
Psoriasis increases the risk of developing various cancers, including colon cancer. The pathogenesis of the co-occurrence of psoriasis and cancer is not yet clear. This study is aimed at analyzing the pathogenesis of psoriasis combined with cancer by bioinformatic analysis. Skin tissue data from psoriasis (GSE117239) and intestinal tissue data from colon cancer (GSE44076) were downloaded from the GEO database. One thousand two hundred ninety-six common differentially expressed genes and 688 common shared genes for psoriasis and colon cancer were determined, respectively, using the limma R package and weighted gene coexpression network analysis (WGCNA) methods. The results of the GO and KEGG enrichment analyses were mainly related to the biological processes of the cell cycle. Thirteen hub genes were selected, including AURKA, DLGAP5, NCAPG, CCNB1, NDC80, BUB1B, TTK, CCNB2, AURKB, TOP2A, ASPM, BUB1, and KIF20A. These hub genes have high diagnostic value, and most of them are positively correlated with activated CD4 T cells. Three hub transcription factors (TFs) were also predicted: E2F1, E2F3, and BRCA1. These hub genes and hub TFs are highly expressed in various cancers. Furthermore, 251 drugs were predicted, and some of them overlap with existing therapeutic drugs for psoriasis or colon cancer. This study revealed some genetic mechanisms of psoriasis and cancer by bioinformatic analysis. These hub genes, hub TFs, and predicted drugs may provide new perspectives for further research on the mechanism and treatment.