表观遗传相关的 IGF2BP3 上调通过调节肝细胞癌中 E2F1 的表达促进细胞增殖。
关键词: E2F1 HCC Methylation Prognosis RNA-binding protein
Mesh : Humans Carcinoma, Hepatocellular / genetics pathology metabolism Liver Neoplasms / genetics pathology metabolism Cell Proliferation / genetics RNA-Binding Proteins / genetics metabolism Gene Expression Regulation, Neoplastic E2F1 Transcription Factor / metabolism genetics Epigenesis, Genetic Male Up-Regulation / genetics Female DNA Methylation Prognosis Cell Line, Tumor Middle Aged Hep G2 Cells Biomarkers, Tumor / genetics metabolism
来 源:
DOI:10.1038/s41598-024-67021-w
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