DeRitis比率,定义为血清天冬氨酸转氨酶(AST)与丙氨酸转氨酶(ALT)的比值,是一种广泛认可的生化标志物,在诊断和管理各种疾病方面具有重要应用,尤其是肝脏疾病。这篇综合综述综合了当前关于DeRitis比率临床相关性的知识,审视其历史发展,诊断实用程序,以及各种医疗条件下的预后意义,包括肝脏疾病,心血管疾病,和肌肉病理。通过对几十年来的文献的深入分析,这篇综述强调了DeRitis比值不仅在鉴别诊断中的作用,而且作为疾病进展和患者结局的预后指标.该比率能够区分不同类型的肝脏病理,帮助早期疾病检测,并讨论了其在监测治疗反应中的潜在用途。此外,审查涉及方法上的考虑,如混杂因素和口译挑战,影响DeRitis比率的临床效用。鉴于临床诊断的发展和对个性化医疗的推动,审查最后提出了进一步研究的建议。这些包括纵向研究,以探索该比率随时间的变化,跨不同人群的比较研究,和技术集成,以提高诊断准确性和病人护理。这篇综述旨在重申DeRitis比率在现代临床实践中的重要性,并鼓励继续探索其在医疗保健中的潜在应用和益处。
The De Ritis ratio, defined as the serum aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio, is a widely recognized biochemical marker with significant applications in diagnosing and managing various diseases, particularly liver disorders. This comprehensive
review synthesizes current knowledge surrounding the clinical relevance of the De Ritis ratio, examining its historical development, diagnostic utility, and prognostic significance across various medical conditions, including liver diseases, cardiovascular disorders, and muscular pathologies. Through an in-depth analysis of literature spanning several decades, this
review highlights the role of the De Ritis ratio not only in differential diagnosis but also as a prognostic indicator for disease progression and patient outcomes. The ratio\'s ability to distinguish between different types of liver pathology, aid in early disease detection, and its potential use in monitoring treatment response are discussed. Additionally, the
review addresses the methodological considerations, such as confounding factors and interpretation challenges, that impact the clinical utility of the De Ritis ratio. Given the evolving landscape of clinical diagnostics and the push toward more personalized medicine, the
review concludes with recommendations for further research. These include longitudinal studies to explore the ratio\'s changes over time, comparative research across diverse populations, and technological integration to enhance diagnostic accuracy and patient care. This
review aims to reaffirm the importance of the De Ritis ratio in modern clinical practice and encourages continued exploration into its potential applications and benefits in healthcare.