Abstract:
Intrahepatic cholestasis of pregnancy (ICP) is a disease specific to pregnancy, featuring maternal itching and elevated serum bile acid levels. It leads to a series of adverse pregnancy outcomes as well as increased fetal mortality. Routine biochemical markers fail to fulfill the tremendous clinical requirements, thereby novel effective biomarkers are urgently desired. In our review, the potential novel biomarkers for ICP diagnosis are classified into four categories and elaborated in detail. The concrete diagnostic performances (sensitivity, specificity and area under the curve) of these biomarkers are demonstrated in tables. Moreover, the relationships between some biomarkers and ICP pathogenesis are briefly expounded. Nevertheless, only a few novel biomarkers are ideal, and their clinical applicability requires more evidence from larger multicenter trials.
摘要:
妊娠肝内胆汁淤积症(ICP)是一种特定于妊娠的疾病,以母体瘙痒和血清胆汁酸水平升高为特征。它导致一系列不良妊娠结局以及增加胎儿死亡率。常规生化标志物不能满足巨大的临床要求,因此,迫切需要新的有效生物标志物。在我们的审查中,ICP诊断的潜在新型生物标志物分为四类并详细阐述.具体的诊断性能(灵敏度,这些生物标志物的特异性和曲线下面积)在表中显示。此外,简要阐述了一些生物标志物与ICP发病机制的关系。然而,只有少数新的生物标志物是理想的,它们的临床适用性需要更多来自大型多中心试验的证据.