Abstract：
Despite advancements, prostate cancers (PCa) pose a significant global health challenge due to delayed diagnosis and therapeutic resistance. This review delves into the complex landscape of prostate cancer, with a focus on long-noncoding RNAs (lncRNAs). Also explores the influence of aberrant lncRNAs expression in progressive PCa stages, impacting traits like proliferation, invasion, metastasis and therapeutic resistance. The study elucidates how lncRNAs modulate crucial molecular effectors, including transcription factors and microRNAs, affecting signaling pathways such as androgen receptor signaling. Besides, this manuscript sheds light on novel concepts and mechanisms driving PCa progression through lncRNAs, providing a critical analysis of their impact on the disease\'s diverse characteristics. Besides, it discusses the potential of lncRNAs as diagnostics and therapeutic targets in PCa. Collectively, this work highlights state of art mechanistic comprehension and rigorous scientific approaches to advance our understanding of PCa and depict innovations in this evolving field of research.
摘要：
尽管取得了进步，前列腺癌（PCa）是一个重要的全球健康由于延迟诊断和治疗耐药性。这篇综述深入研究了前列腺癌的复杂景观，重点关注长非编码RNA（lncRNA）。还探讨了在进行性PCa阶段中异常lncRNAs表达的影响，影响像增殖这样的特征，入侵,转移和治疗抗性。该研究阐明了lncRNAs如何调节关键的分子效应，包括转录因子和microRNA，影响信号通路，如雄激素受体信号。此外,这篇手稿揭示了通过lncRNAs驱动PCa进展的新概念和机制，对它们对疾病的不同特征的影响进行了批判性分析。此外,它讨论了lncRNAs作为PCa诊断和治疗靶标的潜力。总的来说，这项工作突出了最先进的机械理解和严格的科学方法，以促进我们对PCa的理解，并描绘了这个不断发展的研究领域的创新。
