METHODS: Twenty-six eligible studies were included for analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), area under curve (AUC), Q*index, summary receiver-operating characteristic (SROC) were assessed using the Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.3.3 software.
RESULTS: The diagnostic accuracy of microRNA was high in identifying BT based on the pooled sensitivity 0.82 (95%CI: 0.816-0.84), specificity 0.82 (95%CI: 0.817-0.84), PLR 5.101 (95%CI: 3.99-6.51), NLR 0.187 (95%CI: 0.149-0.236), DOR 34.07 (95%CI: 22.56-51.43) as well as AUC (0.92), and Q*-index (0.86). Subgroup analyses were performed for sample types (serum/plasma), reference genes (RNU6, miR-39, and miR-24), and region to determine the diagnostic power of microRNAs in the diagnosis of BT using pooled sensitivity, specificity, PLR, NLR, AUC, and DOR.
CONCLUSIONS: This meta-analysis suggested that circulating microRNAs might be potential markers for noninvasive early detection of BT.
方法:纳入26个符合条件的研究进行分析。汇集的敏感性,特异性,正似然比(PLR),负似然比(NLR),诊断优势比(DOR),曲线下面积(AUC),Q*指数,使用Meta-DiscV.1.4和综合Meta-AnalysisV.3.3软件评估受试者工作特征摘要(SROC)。
结果:根据合并敏感性0.82(95CI:0.816-0.84),microRNA的诊断准确性高,特异性0.82(95CI:0.817-0.84),PLR5.101(95CI:3.99-6.51),NLR0.187(95CI:0.149-0.236),DOR34.07(95CI:22.56-51.43)以及AUC(0.92),和Q*指数(0.86)。对样本类型(血清/血浆)进行亚组分析,参考基因(RNU6、miR-39和miR-24),和区域来确定microRNAs在BT诊断中的诊断能力,特异性,PLR,NLR,AUC,和DOR。
结论:这项荟萃分析提示循环microRNAs可能是BT早期无创检测的潜在标志物。