尽管在巴雷特食管(BE)的诊断和治疗方面取得了重大进展,仍然需要标准化的定义,适当识别内窥镜标志,和分类系统的一致使用。BE基本定义的当前争议以及相对缺乏解剖知识是统一文档的重大障碍。我们旨在为统一报告和全球应用提供共识驱动的建议。
世界内窥镜检查组织Barrett的食管委员会任命领导人开展一项基于证据的Delphi研究。一个由6名成员组成的工作组确定并拟订了23项声明,来自18个国家的30名国际公认专家参加了3轮投票。我们将共识定义为超过80%的专家就每项声明达成一致,并使用建议分级,评估,开发和评估(等级)工具,用于评估证据质量和建议强度。
经过三轮投票,专家就6个内窥镜标志(栅栏血管,胃食管交界处,侧凸交界处,病变位置,腔外按压,和象限方向),13个定义(BE,裂孔疝,鳞状岛屿,柱状岛屿,巴雷特的内窥镜治疗,内镜切除术,内窥镜消融,系统检查,彻底根除肠上皮化生,彻底根除发育不良,残留病,复发性疾病,和内窥镜治疗失败),和4个分类系统(布拉格,洛杉矶,巴黎,和巴雷特的国际NBI集团)。在第一轮中,18项声明(78%)达成共识,有12名(67%)获得了超过一半的专家的强烈同意。在第2轮中,其余4项陈述(80%)达成共识,一份声明得到了50%专家的强烈同意。在第三轮中,就其余声明达成共识。
我们开发了基于证据的,关于内窥镜标志的共识驱动声明,定义,和BE的分类。这些建议可以促进BE的全球统一报告。
Despite the significant advances made in the diagnosis and treatment of Barrett\'s esophagus (BE), there is still a need for standardized
definitions, appropriate recognition of endoscopic landmarks, and consistent use of classification systems. Current controversies in basic
definitions of BE and the relative lack of anatomic knowledge are significant barriers to uniform documentation. We aimed to provide consensus-driven recommendations for uniform reporting and global application.
The World Endoscopy Organization Barrett\'s Esophagus Committee appointed leaders to develop an evidence-based Delphi study. A working group of 6 members identified and formulated 23 statements, and 30 internationally recognized experts from 18 countries participated in 3 rounds of voting. We defined consensus as agreement by ≥80% of experts for each statement and used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tool to assess the quality of evidence and the strength of recommendations.
After 3 rounds of voting, experts achieved consensus on 6 endoscopic landmarks (palisade vessels, gastroesophageal junction, squamocolumnar junction, lesion location, extraluminal compressions, and quadrant orientation), 13
definitions (BE, hiatus hernia, squamous islands, columnar islands, Barrett\'s endoscopic therapy, endoscopic resection, endoscopic ablation, systematic inspection, complete eradication of intestinal metaplasia, complete eradication of dysplasia, residual disease, recurrent disease, and failure of endoscopic therapy), and 4 classification systems (Prague, Los Angeles, Paris, and Barrett\'s International NBI Group). In round 1, 18 statements (78%) reached consensus, with 12 (67%) receiving strong agreement from more than half of the experts. In round 2, 4 of the remaining statements (80%) reached consensus, with 1 statement receiving strong agreement from 50% of the experts. In the third round, a
consensus was reached on the remaining statement.
We developed evidence-based,
consensus-driven statements on endoscopic landmarks,
definitions, and classifications of BE. These recommendations may facilitate global uniform reporting in BE.