PDF(Pubmed)
Abstract：
OBJECTIVE: The aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs).
METHODS: After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method.
RESULTS: Standardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies.
METHODS: After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method.
RESULTS: Standardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies.
摘要：
目的：本文件的目的是制定非中性粒细胞减少的侵袭性真菌病（IFD）的标准化研究定义，没有IFD经典宿主因子的成年患者，入住重症监护病房（ICU）。
方法：在对已有定义和实验室检查的目标人群中IFD的诊断性能进行系统评估之后，共识定义由专家小组使用RAND/UCLA适当性方法制定.
结果：为已证实的侵袭性念珠菌病制定了标准化的研究定义，可能是深层念珠菌病，已经证实的侵袭性曲霉病,可能的侵袭性肺曲霉病，和可能的气管支气管曲霉病。除了念珠菌病和曲霉病以外，关于诊断IFD的现有定义和实验室测试的证据有限，因此无法制定专门的定义。至少等待进一步的数据。本文件提供的标准化定义旨在加快设计速度，并增加可行性，未来的比较研究。
方法：在对已有定义和实验室检查的目标人群中IFD的诊断性能进行系统评估之后，共识定义由专家小组使用RAND/UCLA适当性方法制定.
结果：为已证实的侵袭性念珠菌病制定了标准化的研究定义，可能是深层念珠菌病，已经证实的侵袭性曲霉病,可能的侵袭性肺曲霉病，和可能的气管支气管曲霉病。除了念珠菌病和曲霉病以外，关于诊断IFD的现有定义和实验室测试的证据有限，因此无法制定专门的定义。至少等待进一步的数据。本文件提供的标准化定义旨在加快设计速度，并增加可行性，未来的比较研究。
