姜黄素,分离自姜黄(CurcumalongaL.)是广泛研究的植物分子之一,由于其强大的抗氧化和抗炎潜力,已被认为是广泛疾病的有希望的治疗候选药物。考虑到,它的低生物利用度,已经开发了不同的姜黄素类似物以在不同的病理状态下提供所需的药代动力学特征和治疗结果。一些临床前和临床研究表明,姜黄素改善线粒体功能障碍,炎症,氧化应激凋亡介导的神经细胞变性,可有效用于不同神经退行性疾病的治疗。因此,在这次审查中,我们总结了对姜黄素及其类似物进行的实验和临床研究的关键发现,特别强调分子途径,viz.NF-kB,Nrf2-ARE,胶质激活,凋亡,血管生成,SOCS/JAK/STAT,PI3K/Akt,ERK1/2/MyD88/p38MAPK,JNK,iNOS/NO,和MMP途径参与在神经退行性疾病和相关病症的治疗中赋予改善作用。
Curcumin, isolated from turmeric (Curcuma longa L.) is one of the broadly studied phytomolecule owing to its strong antioxidant and anti-inflammatory potential and has been considered a promising therapeutic candidate in a wide range of disorders. Considering, its low bioavailability, different curcumin analogs have been developed to afford desired pharmacokinetic profile and therapeutic outcome in varied pathological states. Several preclinical and clinical studies have indicated that curcumin ameliorates mitochondrial dysfunction, inflammation, oxidative stress apoptosis-mediated neural cell degeneration and could effectively be utilized in the treatment of different neurodegenerative diseases. Hence, in this
review, we have summarized key findings of experimental and clinical studies conducted on curcumin and its analogues with special emphasis on molecular pathways, viz. NF-kB, Nrf2-ARE, glial activation, apoptosis, angiogenesis, SOCS/JAK/STAT, PI3K/Akt, ERK1/2 /MyD88 /p38 MAPK, JNK, iNOS/NO, and MMP pathways involved in imparting ameliorative effects in the therapy of neurodegenerative disorders and associated conditions.