■为了探索膳食锌摄入量与心血管疾病(CVDs)之间的关系,包括充血性心力衰竭(CHF),冠心病,心绞痛,心脏病发作,脑血管意外(CVA),进行了这项研究.
■这项研究使用了国家健康和营养检查调查(2005-2018年)的数据。膳食锌摄入量被分层为四分位数。构造了受限制的三次样条,以评估非线性关联并根据非线性类型确定截止值。使用截止值进行二元逻辑回归。
■在第二个之间检测到正相关,第三,和第四分位数的膳食锌摄入量和总心血管疾病的风险降低(Q2:OR=0.83,95%CI=0.72-0.96;Q3:OR=0.83,95%CI=0.71-0.96;Q4:OR=0.79,95%CI=0.67-0.93).第二个,第三,和第四分位数与各种CVD的风险降低显着相关(均P<0.05),除冠心病和心绞痛外(均P>0.05)。限制性三次样条回归显示,膳食锌摄入量与发生CVDs和CHF的风险之间存在显著的非线性趋势(非线性均P<0.05),而对于心脏病发作和CVA的那些则有轻微显著性(非线性的P分别为0.072和0.075)。
■这项研究表明,高锌摄入量与降低心血管疾病的风险有关,CHF,心脏病发作,还有CVA,但不是冠心病或心绞痛。
UNASSIGNED: To explore the associations between dietary zinc intake and cardiovascular diseases (CVDs), including congestive heart failure (CHF), coronary heart disease (CHD), angina, heart attack, and cerebrovascular accident (CVA), this
study was performed.
UNASSIGNED: Data from the National Health and Nutrition Examination Survey (2005-2018) were used in this
study. Dietary zinc intake was stratified into quartiles. Restricted cubic splines were constructed to assess nonlinear associations and identify cut-off values based on the type of nonlinearity. Binary logistic regressions were performed using the cut-offs.
UNASSIGNED: Positive associations were detected between the second, third, and fourth quantiles of dietary zinc intake and decreased risks of overall CVDs (Q2: OR = 0.83, 95 % CI = 0.72-0.96; Q3: OR = 0.83, 95 % CI = 0.71-0.96; Q4: OR = 0.79, 95 % CI = 0.67-0.93). The second, third, and fourth quantiles were significantly associated with decreased risks of various CVDs (all P < 0.05), except for CHD and angina (all P > 0.05). Restricted cubic spline regression revealed significant nonlinear trends for associations of dietary zinc intake with the risk of developing CVDs and CHF (both P for nonlinear <0.05), whereas those for heart attack and CVA were marginally significant (P for nonlinear = 0.072, and 0.075, respectively).
UNASSIGNED: This
study revealed that high dietary zinc intake is associated with reduced risks of developing CVDs, CHF, heart attack, and CVA, but not CHD or angina.