Abstract：
OBJECTIVE: To study the relationships of an Atherogenicity Index (ATI) and a Thrombogenicity Index (THI), with 50-year mortality from coronary heart disease (CHD), other heart diseases of uncertain etiology (HDUE) and cerebrovascular disease or stroke (STR), in 16 international cohorts of middle-aged men.
RESULTS: Foods from a dietary survey in subsamples of men in each cohort of the Seven Countries Study (SCS) were chemically analyzed for several types of fatty acids that were converted into ATI and THI identifying each of 16 cohorts. Ecological correlations of the ATI and THI were calculated with the three fatal CVD conditions and with all-cause mortality at 25 and 50 years. Correlation coefficients (Rs) were positive and highly significant between ATI and THI versus CHD mortality, with levels ranging from 0.79 to 0.97, depending on the duration of follow-up and the choice of 10 or of 16 cohorts. This was not the case for HDUE and STR mortality for which Rs were variable and not significant. A strong direct association was also found with all-causes deaths at 25 and 50-years. ATI and THI were also directly related with dietary saturated fat and cholesterol levels and inversely with the Mediterranean Adequacy Index (a score identifying the Mediterranean diet).
CONCLUSIONS: These findings indicate that CHD has a different relationship with dietary lipids intake than HDUE and STR. This suggests that HDUE and STR have different underlying pathways or are different diseases.
RESULTS: Foods from a dietary survey in subsamples of men in each cohort of the Seven Countries Study (SCS) were chemically analyzed for several types of fatty acids that were converted into ATI and THI identifying each of 16 cohorts. Ecological correlations of the ATI and THI were calculated with the three fatal CVD conditions and with all-cause mortality at 25 and 50 years. Correlation coefficients (Rs) were positive and highly significant between ATI and THI versus CHD mortality, with levels ranging from 0.79 to 0.97, depending on the duration of follow-up and the choice of 10 or of 16 cohorts. This was not the case for HDUE and STR mortality for which Rs were variable and not significant. A strong direct association was also found with all-causes deaths at 25 and 50-years. ATI and THI were also directly related with dietary saturated fat and cholesterol levels and inversely with the Mediterranean Adequacy Index (a score identifying the Mediterranean diet).
CONCLUSIONS: These findings indicate that CHD has a different relationship with dietary lipids intake than HDUE and STR. This suggests that HDUE and STR have different underlying pathways or are different diseases.
摘要：
目的：为了研究动脉粥样硬化指数（ATI）和血栓形成指数（THI）的关系，冠心病（CHD）的50年死亡率，其他病因不明的心脏病（HDUE）和脑血管疾病或中风（STR），在16个国际中年男性队列中。
结果：对七国研究（SCS）每个队列中男性子样本的饮食调查中的食品进行了化学分析，分析了几种类型的脂肪酸，这些脂肪酸被转化为ATI和THI，确定了16个队列中的每一个。ATI和THI的生态相关性是与三种致命的CVD条件以及25年和50年全因死亡率计算的。ATI和THI与CHD死亡率之间的相关系数（Rs）为正，且高度显着。水平从0.79到0.97，取决于随访的持续时间和10个或16个队列的选择。HDUE和STR死亡率的情况并非如此，Rs是可变的且不显著。还发现与25岁和50岁的全因死亡有很强的直接关联。ATI和THI也与饮食饱和脂肪和胆固醇水平直接相关，与地中海充足指数（确定地中海饮食的得分）成反比。
结论：这些研究结果表明，与HDUE和STR相比，冠心病与膳食脂质摄入的关系不同。这表明HDUE和STR具有不同的潜在途径或者是不同的疾病。
结果：对七国研究（SCS）每个队列中男性子样本的饮食调查中的食品进行了化学分析，分析了几种类型的脂肪酸，这些脂肪酸被转化为ATI和THI，确定了16个队列中的每一个。ATI和THI的生态相关性是与三种致命的CVD条件以及25年和50年全因死亡率计算的。ATI和THI与CHD死亡率之间的相关系数（Rs）为正，且高度显着。水平从0.79到0.97，取决于随访的持续时间和10个或16个队列的选择。HDUE和STR死亡率的情况并非如此，Rs是可变的且不显著。还发现与25岁和50岁的全因死亡有很强的直接关联。ATI和THI也与饮食饱和脂肪和胆固醇水平直接相关，与地中海充足指数（确定地中海饮食的得分）成反比。
结论：这些研究结果表明，与HDUE和STR相比，冠心病与膳食脂质摄入的关系不同。这表明HDUE和STR具有不同的潜在途径或者是不同的疾病。
