生物治疗时代类风湿关节炎(RA)患者疲劳患病率的数据仍然很少,缺乏病例对照研究。这项研究使用慢性疾病治疗-疲劳功能评估(FACIT-F)量表评估了西班牙50岁以上RA女性的疲劳患病率,探索其与RA相关变量的关联,并试图找出影响疲劳的主要因素。最终,我们的目标是强调疲劳作为合并症的临床意义,并倡导在常规临床实践中对其进行系统评价.
■在一所三级大学医院的一项病例对照研究中,使用FACIT-F量表评估了191名50岁以上(平均年龄:67.5±8.8岁)符合ACR2010RA标准的女性和年龄匹配的对照组。SF-12问卷,和RA相关的临床措施。
■与对照组相比,RA组(61%)的疲劳明显更普遍(37%,p<0.001),RA患者平均FACIT-F评分较低(36.0±10.6vs.40.0±0.6,p<0.001)。FACIT-F评分与C反应蛋白之间存在相关性,DAS28,RAPID3,HAQ,和SF-12得分。进行多变量分析并生成四个模型。最终的模型,R2为0.817,表明疲劳受疾病活动(RAPID3),身心健康(SF12)和年龄的影响显着,解释了81.7%的疲劳变异。
在50岁以上的RA女性中,疲劳仍然非常普遍和严重,与疾病活动密切相关,残疾,生活质量下降。临床环境中的系统性疲劳评估和针对性策略对于解决这一普遍问题至关重要。未来的研究应该探索针对这一人群的针对性干预措施,以提高护理质量。
UNASSIGNED: Data on prevalence of fatigue in rheumatoid arthritis (RA) patients in the era of biological treatments remains scarce, with a lack of
case-control studies. This study evaluates the prevalence of fatigue in Spanish women over 50 years with RA using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale, explores its association with RA-related variables, and seeks to identify the primary factors influencing fatigue. Ultimately, our objective is to underscore the clinical significance of fatigue as a comorbidity and to advocate for its systematic evaluation in routine clinical practice.
UNASSIGNED: In a
case-control study at a tertiary university hospital, 191 women over 50 years (mean age: 67.5 ± 8.8 years) meeting ACR 2010 criteria for RA and age-matched controls were assessed using the FACIT-F scale, SF-12 questionnaire, and RA-related clinical measures.
UNASSIGNED: Fatigue was significantly more prevalent in the RA group (61%) compared to controls (37%, p < 0.001), with RA patients showing lower mean FACIT-F scores (36.0 ± 10.6 vs. 40.0 ± 0.6, p < 0.001). Correlations were noted between FACIT-F scores and C-reactive protein, DAS28, RAPID3, HAQ, and SF-12 scores. A multivariate analysis was performed and four models generated. The final model, with an R2 of 0.817, indicates that fatigue is significantly influenced by disease activity (RAPID 3) and mental and physical health (SF12) and age, explaining 81.7% of the variance in fatigue.
UNASSIGNED: Fatigue remains significantly prevalent and severe in women over 50 years with RA, strongly linked to disease activity, disability, and diminished quality of life. Systematic fatigue assessment and targeted strategies in clinical settings are essential to address this widespread issue. Future research should explore targeted interventions tailored to this demographic to enhance quality of care.