UNASSIGNED: This was a case-control, multicenter study conducted in 11 anti-TB centers in Tunisia (June-November2014). The cases were adults aged between 18 and 55 years with newly diagnosed and confirmed tuberculosis. Controls were free from tuberculosis. A data collection sheet was filled out and a TST was performed for each participant.Diagnostic accuracy measures of TST were estimated using Receiver Operating Curve (ROC) curve and Area Under Curve (AUC) to estimate sensitivity and specificity of a determined cut-off point.
UNASSIGNED: Overall, 1050 patients were enrolled, composed of 336 cases and 714 controls. The mean age was 38.3±11.8 years for cases and 33.6±11 years for controls.The mean diameter of the TST induration was significantly higher among cases than controls (13.7mm vs.6.2mm; p=10 -6). AUC was 0.789 [95% CI: 0.758-0.819; p=0.01], corresponding to a moderate discriminating performance for this test. The most discriminative cut-off value of the TST, which was associated with the best sensitivity (73.7%) and specificity (76.6%) couple was ≥ 11 mm with a Youden index of 0.503. Positive and Negative predictive values were 3.11% and 99.52%, respectively.
UNASSIGNED: TST could be a useful tool used for active tuberculosis detection, with a moderate global performance and accepted sensitivity and specificity at the cut-off point of 11 mm. However, it cannot be considered as a gold standard test due to its multiple disadvantages.
■这是病例对照,在突尼斯11个抗结核中心进行的多中心研究(2014年6月至11月)。这些病例为18至55岁的成年人,患有新诊断和确诊的结核病。对照没有结核病。填写了数据收集表,并对每个参与者进行了TST。使用受试者工作曲线(ROC)曲线和曲线下面积(AUC)估计TST的诊断准确性测量,以估计确定的截止点的灵敏度和特异性。
■总的来说,纳入1050名患者,由336例病例和714例对照组成。病例的平均年龄为38.3±11.8岁,对照组为33.6±11岁。病例中TST硬结的平均直径明显高于对照组(13.7mmvs.6.2mm;p=10-6)。AUC为0.789[95%CI:0.758-0.819;p=0.01],对应于该测试的中等辨别性能。TST的最有区别的截止值,与最佳敏感性(73.7%)和特异性(76.6%)相关的夫妇≥11mm,Youden指数为0.503。阳性预测值和阴性预测值分别为3.11%和99.52%,分别。
■TST可能是用于主动结核病检测的有用工具,在11mm的截止点具有中等的全局性能和公认的灵敏度和特异性。然而,由于其多重缺点,它不能被视为黄金标准测试。