背景:作为糖尿病的常见并发症,糖尿病性心肌病(DCM)常导致心肌进一步损伤。姜黄素已经被证明具有多种心脏保护作用,然而,对DCM的保护作用尚未进行系统评价。
目的:在本研究中,我们旨在分析姜黄素治疗DCM的临床前(动物模型)证据。
方法:从图书馆建设到2023年11月1日,搜索了八个数据库和两个注册系统。我们进行了严格的数据提取和质量评估。纳入的研究方法学质量使用SYRCLERoB工具进行评估,使用RevMan5.4软件进行统计分析,使用Stata17.0软件进行漏斗图和Egger检验以评估发表偏倚。
结果:本研究包括32项试验,共681只动物。Meta分析显示姜黄素显著改善心功能指标(LVEF,LVFS,和LVSd)(p<0.01),心肌损伤标志物减少,硬件/带宽比,与对照组相比,随机血糖,除了显示对心肌氧化机制指标的有益影响外,炎症,凋亡,和自噬(p<0.05)。
结论:姜黄素可能通过其抗氧化作用对DCM发挥心脏保护作用。抗炎,自噬增强,和抗凋亡作用。它的保护作用与剂量成正比,并且在超过200mg/kg的浓度下,功效可能会进一步增加,需要进一步验证。
BACKGROUND: As a common complication of diabetes, diabetic cardiomyopathy (DCM) often leads to further damage to the heart muscle. Curcumin has been proven to have a variety of cardioprotective effects, however, the protective effect against DCM has not been systematically reviewed.
OBJECTIVE: In this study, we aimed to analyze the preclinical (animal model) evidence of curcumin\'s therapeutic effects in DCM.
METHODS: Eight databases and two registry systems were searched from the time of library construction to 1 November 2023. We performed rigorous data extraction and quality assessment. The included studies\' methodological quality was appraised using the SYRCLE RoB tool, statistical analyses were carried out using RevMan 5.4 software, and Funnel plots and Egger\'s test were performed using Stata 17.0 software to assess publication bias.
RESULTS: This study included 32 trials with a total of 681 animals. Meta-analysis showed that curcumin significantly improved cardiac function indices (LVEF, LVFS, and LVSd) (p < 0.01), decreased markers of myocardial injury, HW/BW ratio, and randomized blood glucose compared to the control group, in addition to showing beneficial effects on mechanistic indices of myocardial oxidation, inflammation, apoptosis, and autophagy (p < 0.05).
CONCLUSIONS: Curcumin may exert cardioprotective effects in DCM through its antioxidant, anti-inflammatory, autophagy-enhancing, and anti-apoptotic effects. Its protective effect is proportional to the dose, and the efficacy may be further increased at a concentration of more than 200 mg/kg, and further validation is needed.