PDF(Pubmed)
Abstract：
Doxorubicin (DOX) is an anthracycline anticancer agent that is highly effective in the treatment of solid tumors. Given the multiplicity of mechanisms involved in doxorubicin-induced cardiotoxicity, it is difficult to identify a precise molecular target for toxicity. The findings of a literature review suggest that natural products may offer cardioprotective benefits against doxorubicin-induced cardiotoxicity, both in vitro and in vivo. However, further confirmatory studies are required to substantiate this claim. It is of the utmost importance to direct greater attention towards the intricate signaling networks that are of paramount importance for the survival and dysfunction of cardiomyocytes. Notwithstanding encouraging progress made in preclinical studies of natural products for the prevention of DOX-induced cardiotoxicity, these have not yet been translated for clinical use. One of the most significant obstacles hindering the development of cardioprotective adjuvants based on natural products is the lack of adequate bioavailability in humans. This review presents an overview of current knowledge on doxorubicin DOX-induced cardiotoxicity, with a focus on the potential benefits of natural compounds and herbal preparations in preventing this adverse effect. As literature search engines, the browsers in the Scopus, PubMed, Web of Science databases and the ClinicalTrials.gov register were used.
摘要：
阿霉素（DOX）是一种蒽环类抗癌剂，在治疗实体肿瘤中非常有效。鉴于多柔比星诱导的心脏毒性涉及多种机制，很难确定毒性的精确分子靶标。文献综述的结果表明，天然产物可能对阿霉素诱导的心脏毒性提供心脏保护作用。在体外和体内。然而,需要进一步的验证性研究来证实这一说法。最重要的是将更多的注意力转向复杂的信号网络，这些信号网络对于心肌细胞的存活和功能障碍至关重要。尽管在预防DOX引起的心脏毒性的天然产物的临床前研究中取得了令人鼓舞的进展，这些尚未翻译为临床使用。阻碍开发基于天然产物的心脏保护性佐剂的最重要障碍之一是在人体中缺乏足够的生物利用度。这篇综述概述了关于多柔比星DOX诱导的心脏毒性的最新知识，重点关注天然化合物和草药制剂在预防这种不良反应方面的潜在益处。作为文献搜索引擎，Scopus中的浏览器，PubMed,使用了WebofScience数据库和ClinicalTrials.gov寄存器。
