■本病例报告的目的是介绍一个有趣的双膦酸盐相关性颌骨坏死病例,涉及上颌和上颌窦,由于每个操作系统服用伊班膦酸。
■一位女性患者,62岁,被转诊到齿槽外科,外科种植和放射学,牙科学院,塞萨洛尼基亚里士多德大学,希腊,抱怨第一象限的疼痛.她的病史显示过去四年来一直服用双膦酸盐。随后,锥形束计算机断层扫描检查显示了一个小的骨死区,被射线透射包围,靠近窦底.临床检查未发现任何病理临床体征。
■根据放射学检查,实施了手术方法来去除坏死的骨,用盐水冲洗肺泡和窦,并最终实现主闭包,之后,病人痊愈顺利。骨坏死归因于双膦酸盐给药。
■对牙龈组织无明显或轻微影响的双膦酸盐相关性颌骨坏死是一个诊断挑战,表明这种不良反应的早期阶段。成像对于早期发现这些病例至关重要。在仔细选择病例后,适当的外科手术可以有效地消除骨骼破坏的未来发展。预防颌骨坏死可以通过向牙科医生提供足够的教育来实现,医生,和病人。
UNASSIGNED: The aim of this
case report is to present an interesting
case of bisphosphonate-related osteonecrosis of the jaw, involving the maxilla and the maxillary sinus, as a result of per os administration of ibandronic acid.
UNASSIGNED: A female patient, 62 years old, was referred to the Department of Dentoalveolar Surgery, Surgical Implantology and Radiology, School of Dentistry, Aristotle University of Thessaloniki, Greece, complaining about pain in the first quadrant. Her medical history revealed per os bisphosphonate administration for the past four years. Subsequently, the cone-beam computed tomography examination revealed a small sequestrum of bone, surrounded by radiolucency, in proximity with the sinus floor. The clinical examination didn\'t reveal any pathological clinical signs.
UNASSIGNED: Based on the radiological examination, a surgical approach was implemented to remove the necrotic bone, irrigate the alveolar process and the sinus with saline, and finally achieve primary closure, after which, the patient healed uneventfully. The osteonecrosis was attributed to the bisphosphonate administration.
UNASSIGNED: Bisphosphonate-related osteonecrosis of the jaw without obvious or with minor implication of gingival tissues is a diagnostic challenge indicating an early stage of this adverse reaction. Imaging is critical for the early detection of those cases. After careful choice of the
case the proper surgical intervention could be effective to eliminate a future advancement of bone destruction. The prevention of osteonecrosis of the jaw can be achieved through the provision of adequate education to dental medicine practitioners, medical doctors, and patients.