Mesh : Humans Jaw Diseases / chemically induced Osteonecrosis / chemically induced diagnostic imaging Diphosphonates / adverse effects Antibodies, Monoclonal / adverse effects Bone Density Conservation Agents / adverse effects Bisphosphonate-Associated Osteonecrosis of the Jaw / etiology Jaw / pathology

来  源:   DOI:10.1016/j.oooo.2023.05.017

Abstract:
Medication-related osteonecrosis of the jaw is an uncommon but highly morbid adverse event of certain medical therapies. Although classically induced by bisphosphonates, the recent advent of monoclonal antibodies is contributing to a rise in cases. In this case report, we present a rare case of golimumab-associated medication-related osteonecrosis of the jaw and discuss the possible mechanisms of pathogenesis.
摘要:
药物相关的颌骨坏死是某些药物治疗的罕见但高度病态的不良事件。虽然传统上是由双膦酸盐引起的,最近单克隆抗体的出现导致了病例的增加。在这个案例报告中,我们介绍了一例罕见的戈利木单抗相关药物相关性颌骨坏死病例,并讨论了可能的发病机制.
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