目的:众所周知,膳食纤维对微生物组和整个健康产生积极影响。然而,β-葡聚糖对健康的影响,从燕麦中提取的膳食纤维,在单独服用或加入其他食物时受到质疑。本系统评价和荟萃分析的目的是评估燕麦或β-葡聚糖补充剂对血脂的影响。
方法:采用平行臂或交叉盲法干预的随机对照试验至少持续两周,对于高脂血症或非高脂血症,选择≥18岁的男性和女性.本综述仅考虑将燕麦或分离的β-葡聚糖与安慰剂/对照组进行比较的单(参与者盲法)或双盲研究。数据库EMBASE,PubMed,搜索了科学网和CINHAL,从网上最早的索引年份到2022年1月底。随机效应模型用于结合从单个研究中提取的估计效应,数据汇总为标准化均差(SMD)和95%置信区间(95CI).
结果:共筛选出811篇文章,从28项研究中提取相关数据,共1494个科目。燕麦干预TC(-0.61,95CI:-0.84;-0.39,p<0.00001,和-0.70,95CI:-1.07;-0.34,p=0.0002,分别)和LDL(-0.51,95CI:-0.71;-0.31,p<0.00001,和-0.38,95CI:-0.60;-0.15,p=0.001)。此外,从平行臂研究中分离的β-葡聚糖干预降低了TC(-0.73,95CI:-1.01;-0.45,p<0.00001),LDL(-0.58,95CI:-0.85;-0.32,p<0.0001)和甘油三酯(-0.30,95CI:-0.49;-0.12,p=0.001)。HDL未被燕麦或分离的β-葡聚糖改变(p>0.05)。
结论:总体而言,这篇综述显示,燕麦和分离的β-葡聚糖干预均可改善血脂状况.此外,摄入燕麦或分离的β-葡聚糖补充剂是对抗血脂异常的有效工具,在心血管疾病预防中应考虑。
It is well known that dietary fiber positively impacts the microbiome and health as a whole. However, the health effects of β-glucan, a dietary fiber extracted from oats, have been questioned when administered alone or incorporated into other foods. The purpose of this systematic
review and meta-analysis was to evaluate the impact of oats or β-glucan supplements on the lipid profile.
Randomized controlled trials with parallel-arm or crossover blinded interventions at least two weeks in duration, for hyperlipidemic or non-hyperlipidemic men and women ≥18 years of age were selected. Only single (participants blinded) or double-blinded studies that compared oat or isolated β-glucan with a placebo/control group were considered for this
review. The databases EMBASE, PubMed, Web of science and CINHAL were searched, from the earliest indexed year available online to the end of January 2022. Random-effects models were used to combine the estimated effects extracted from individual studies, and data were summarized as standardized mean difference (SMD) and 95% confidence interval (95%CI).
A total of 811 articles were screened for eligibility, and relevant data were extracted from 28 studies, totaling 1494 subjects. Oat interventions TC (-0.61, 95%CI: -0.84;-0.39, p < 0.00001, and -0.70, 95%CI: -1.07;-0.34, p = 0.0002, respectively) and LDL (-0.51, 95%CI: -0.71;-0.31, p < 0.00001, and -0.38, 95%CI: -0.60;-0.15, p = 0.001, respectively). Moreover, isolated β-glucan interventions from parallel-arm studies decreased TC (-0.73, 95%CI: -1.01;-0.45, p < 0.00001), LDL (-0.58, 95%CI: -0.85;-0.32, p < 0.0001) and triglycerides (-0.30, 95%CI: -0.49;-0.12, p = 0.001). HDL was not altered by either oat or isolated β-glucan (p > 0.05).
Overall, this
review showed that both oat and isolated β-glucan interventions improved lipid profiles. Furthermore, the ingestion of oats or isolated β-glucan supplements are effective tools to combat dyslipidemia and should be considered in cardiovascular disease prevention.