背景:山茱萸(Corneliancherry,CM)水果在许多欧洲和亚洲国家被用作传统美食和民间药物已有数十年的历史。CM具有抗氧化剂,抗糖尿病,抗炎,抗肥胖,和降血脂活性由于其丰富的生物活性化合物,和CM水果等部位已被用于预防和治疗多种疾病的民间医学。肥胖,胰岛素抵抗,炎症与代谢相关的脂肪肝(MAFLD)密切相关,因此,CM可能是MAFLD患者的希望。
目的:本研究旨在评估含/不含饮食疗法的冻干CM果粉对MAFLD患者生化指标和人体测量的影响。
方法:本随机临床试验对87例MAFLD患者和21例健康个体进行。患者被随机分为4组:1组接受30g/d冻干CM果粉加饮食治疗,第二组只接受饮食疗法,组-3只接受30克/天冻干CM果粉,和第4组未进行任何药物治疗和饮食治疗或冻干CM水果粉8周。生化参数,在基线和干预后进行人体测量。
结果:干预8周后,体重显著下降,身体质量指数,身体脂肪量,腰围和臀围,空腹血糖,胰岛素,hbA1c,肝酶,总甘油三酯,低密度脂蛋白,在第1、2和3组中发现了总胆固醇。
结论:冻干CM果粉除饮食疗法外,仅饮食疗法对MAFLD患者的人体测量和生化指标具有积极且相似的影响。此外,仅冻干CM果粉改善血糖参数。因此,冻干CM果粉可能对MAFLD成年患者有益。
BACKGROUND: Cornus mas L. (Cornelian cherry, CM) fruits have been utilized for decades in numerous European and Asian countries as traditional cuisine and folk medicine. CM has antioxidant, anti-diabetic, anti-inflammatory, anti-obesity, and hypolipidemic activities due to its rich bioactive compounds, and CM fruits and other parts have been used for the prevention and treatment of a diverse variety of diseases in folk medicine. Obesity, insulin resistance, and inflammation are strongly associated with metabolic-associated fatty liver disease (MAFLD), therefore, CM may be hope for MAFLD patients.
OBJECTIVE: The
study aimed to evaluate the effect of lyophilized CM fruit powder with/without diet therapy on biochemical parameters and anthropometric measurements in patients with MAFLD.
METHODS: This randomized clinical
trial was conducted on 87 patients with MAFLD and 21 healthy individuals. Patients were randomly assigned into 4 groups: group-1 receiving 30 g/d lyophilized CM fruit powder plus diet therapy, group-2 receiving only diet therapy, group-3 receiving only 30 g/d lyophilized CM fruit powder, and group-4 had not undertaken any pharmacological treatment and diet therapy or lyophilized CM fruit powder for 8 weeks. Biochemical parameters, and anthropometric measurements at baseline and after the intervention were taken.
RESULTS: After 8 weeks of intervention, a significant decrease in body weight, body mass index, body fat mass, waist and hip circumferences, fasting blood glucose, insulin, hbA1c, liver enzymes, total triglycerides, low-density lipoprotein, total cholesterol were found in group-1, 2 and 3.
CONCLUSIONS: Lyophilized CM fruit powder in addition to diet therapy and only diet therapy had a positive and similar effect on anthropometric measurements and biochemical parameters in MAFLD patients. Furthermore, only lyophilized CM fruit powder improved glycemic parameters. Therefore, lyophilized CM fruit powder may be beneficial for adult patients with MAFLD.