背景:Aicardi综合征是一种遗传性畸形综合征,具有call体发育不全或发育不全的三联症,独特的脉络膜视网膜腔隙和婴儿痉挛。这是一种罕见的发育障碍,最早于1965年描述。该疾病影响100,000个活产中的1个。
方法:我们描述了一个诊断为Aicardi综合征的34个月大女孩。
方法:根据眼底彩色图像的结果,病史以及核型和DNA微阵列分析,患者被诊断为Aicardi综合征。
方法:另外还进行了B超和电生理检查。
结果:眼底镜检查显示双眼视盘缺损,后极广泛的脉络膜视网膜腔隙伴视网膜色素上皮重组和萎缩。闪光视觉诱发电位(FVEP)P2振幅低于正常范围。B超检查显示视盘病变与视盘缺损一致。
结论:先天性中枢神经系统畸形患儿应定期进行眼科检查,以利于诊断和判断视功能发育的预后。
BACKGROUND: Aicardi syndrome is a genetic malformation syndrome with a triad of dysgenesis or agenesis of the corpus callosum, distinctive chorioretinal lacunae and infantile spasms. It is a rare developmental disorder first described in 1965. The disease affects 1 in 100,000 live births.
METHODS: We describe a 34-month-old girl diagnosed with Aicardi Syndrome.
METHODS: Based on the results of color images of the fundus, medical history as well as the analysis of karyotype and DNA microarrays, the patient was diagnosed with Aicardi\'s syndrome.
METHODS: Additionally an B-scan ultrasonography and an electrophysiological test was performed.
RESULTS: Fundoscopic examination revealed optic disc colobomas in both eyes, extensive chorioretinal lacunae at the posterior pole with retinal pigment epithelium regrouping and atrophy. Flash visual evoked potentials (FVEP) P2 amplitude was lower than normal range. B-scan ultrasonography revealed an optic disc lesion consistent with optic disk coloboma.
CONCLUSIONS: Children with congenital central nervous system malformations should undergo regular ophthalmic checkups to facilitate diagnosis and determine prognosis of visual function development.