{Reference Type}: Journal Article
{Title}: Prenatal diagnosis of Aicardi syndrome based on a suggestive imaging pattern: A multicenter case-series.
{Author}: Pomar L;Ochoa J;Cabet S;Huisman TAGM;Paladini D;Klaritsch P;Galmiche A;Prayer F;Gacio S;Haratz K;Malinger G;Van Mieghem T;Baud D;Bromley B;Lebon S;Dubruc E;Vial Y;Guibaud L;
{Journal}: Prenat Diagn
{Volume}: 42
{Issue}: 4
{Year}: 04 2022
{Factor}: 3.242
{DOI}: 10.1002/pd.6085
{Abstract}: To characterize a suggestive prenatal imaging pattern of Aicardi syndrome using ultrasound and MR imaging.<BR>Based on a retrospective international series of Aicardi syndrome cases from tertiary centers encountered over a 20-year period (2000-2020), we investigated the frequencies of the imaging features in order to characterize an imaging pattern highly suggestive of the diagnosis.<BR>Among 20 cases included, arachnoid cysts associated with a distortion of the interhemispheric fissure were constantly encountered associated with complete or partial agenesis of the corpus callosum (19/20, 95%). This triad in the presence of other CNS disorganization, such as polymicrogyria (16/17, 94%), heterotopias (15/17, 88%), ventriculomegaly (14/20, 70%), cerebral asymmetry [14/20, 70%]) and less frequently extra-CNS anomaly (ocular anomalies [7/11, 64%], costal/vertebral segmentation defect [4/20, 20%]) represent a highly suggestive pattern of Aicardi syndrome in a female patient.<BR>Despite absence of genetic test to confirm prenatal diagnosis of AS, this combination of CNS and extra-CNS fetal findings allows delineation of a characteristic imaging pattern of AS, especially when facing dysgenesis of the corpus callosum.